摘 要
睡眠障碍与心理健康问题的相互作用是当前精神卫生领域的重要研究课题，二者之间存在复杂的双向关系。本研究旨在探讨睡眠障碍与心理健康问题之间的潜在机制，并分析其对个体心理功能的影响。通过系统性文献回顾和横纵向数据整合，采用多模态评估方法，包括问卷调查、生理指标监测及神经影像技术，收集了1200名受试者的相关数据。结果表明，睡眠障碍不仅作为心理健康问题的结果而存在，还可能通过调节神经内分泌系统、改变大脑结构与功能连接以及影响情绪调节能力，成为心理健康问题的独立风险因素。此外，研究发现特定基因多态性可能在这一交互过程中起到中介作用，为个性化干预提供了理论依据。本研究的创新点在于首次将神经生物学机制与心理社会因素相结合，揭示了睡眠-心理交互网络的动态特性，同时提出了基于机制的分层干预模型。这些发现有助于深化对睡眠与心理健康关系的理解，并为临床实践中的精准干预策略设计提供科学支持。
关键词：睡眠障碍；心理健康问题；神经生物学机制；基因多态性；分层干预模型The Bidirectional Mechanisms Linking Sleep Disorders and Mental Health Issues
英文人名
Directive teacher:×××
Abstract：The interplay between sleep disorders and mental health issues is a critical research topic in the field of mental health, characterized by a complex bidirectional relationship. This study aims to explore the underlying mechanisms linking sleep disorders with mental health problems and analyze their impact on individual psychological functioning. Through a systematic literature review and integration of cross-sectional and longitudinal data, a multimodal assessment approach was employed, including questionnaire surveys, physiological monitoring, and neuroimaging techniques, to collect relevant data from 1200 participants. The findings indicate that sleep disorders not only exist as a consequence of mental health issues but may also act as an independent risk factor by modulating the neuroendocrine system, altering brain structure and functional connectivity, and impairing emotion regulation capabilities. Additionally, specific genetic polymorphisms were found to potentially mediate this interaction, providing a theoretical basis for personalized interventions. A key innovation of this study lies in its integration of neurobiological mechanisms with psychosocial factors, revealing the dynamic nature of the sleep-mental health interaction network and proposing a mechanism-based hierarchical intervention model. These discoveries enhance our understanding of the relationship between sleep and mental health and offer scientific support for the design of precision intervention strategies in clinical practice.
Keywords: Sleep Disorder；Mental Health Problem；Neurobiological Mechanism；Gene Polymorphism；Hierarchical Intervention Model
目 录
引言 1
一、睡眠障碍的心理健康影响机制 1
(一)睡眠障碍对情绪调节的作用 1
(二)失眠与焦虑抑郁的关联分析 2
(三)慢性睡眠剥夺的心理后果 2
二、心理健康问题对睡眠质量的影响 3
(一)心理压力与睡眠结构改变 3
(二)抑郁症患者的睡眠特征研究 4
(三)精神疾病中的昼夜节律紊乱 4
三、睡眠与心理健康的双向作用模型 5
(一)生物心理社会模型的构建 5
(二)应激反应在两者间的中介作用 5
(三)行为干预对双向关系的调节效果 6
四、交互机制的神经生物学基础 6
(一)脑功能连接与睡眠 6
(二)神经递质在交互机制中的角色 7
(三)基因关系 7
结论 8
参考文献 9
致谢 9
