摘 要
肝硬化腹水是临床常见的并发症，严重影响患者生活质量及预后。传统治疗方法虽有一定疗效，但存在副作用大、复发率高等问题，亟需探索更优的治疗策略。本研究旨在探讨一种基于个体化诊疗的新型综合疗法在肝硬化腹水治疗中的应用效果。研究选取120例肝硬化腹水患者，随机分为对照组和实验组，对照组采用常规利尿剂联合限盐治疗，实验组在此基础上结合经颈静脉肝内门体分流术（TIPS）与中药调理。通过为期6个月的随访观察，评估两组患者的腹水消退情况、肝功能改善程度及不良反应发生率。结果显示，实验组腹水完全缓解率为85.0%，显著高于对照组的60.0%（P0.05），且肝功能指标如白蛋白水平和Child-Pugh评分均得到明显改善。此外，实验组未出现严重并发症，表明该疗法安全性较高。本研究创新性地将TIPS与中药调理相结合，充分发挥了中西医协同作用，为肝硬化腹水的临床治疗提供了新思路，具有重要的实践意义。关键词：肝硬化腹水; 个体化诊疗; TIPS
Abstract
Ascites due to liver cirrhosis is a common clinical complication that significantly impairs patients' quality of life and prognosis. Although conventional treatments have achieved some efficacy, they are associated with significant side effects and high recurrence rates, necessitating the exploration of more optimal therapeutic strategies. This study aimed to evaluate the application effect of a novel integrated therapy based on individualized diagnosis and treatment for ascites in liver cirrhosis. A total of 120 patients with cirrhotic ascites were randomly divided into a control group and an experimental group. The control group received standard diuretic therapy combined with salt restriction, while the experimental group additionally underwent transjugular intrahepatic portosystemic shunt (TIPS) along with traditional Chinese medicine regulation. Patients were followed up for six months to assess the resolution of ascites, improvement in liver function, and incidence of adverse reactions. Results showed that the complete remission rate of ascites in the experimental group was 85.0%, which was significantly higher than 60.0% in the control group (P0.05). Moreover, liver function indicators, such as albumin levels and Child-Pugh scores, were markedly improved in the experimental group. Additionally, no severe complications occurred in the experimental group, indicating a relatively high safety profile of this therapy. This study innovatively combined TIPS with traditional Chinese medicine regulation, effectively leveraging the synergistic effects of Western and traditional Chinese medicine, thus providing new insights into the clinical management of ascites in liver cirrhosis and demonstrating important practical significance.
Key words:Liver Cirrhosis Ascites; Individualized Diagnosis And Treatment; TIPS
中文摘要 I
英文摘要 II
引 言 1
第1章、肝硬化腹水的病理机制分析 2
1.1、肝硬化腹水形成机制 2
1.2、病理生理特征研究 2
1.3、当前治疗局限性探讨 2
第2章、新治疗方法的理论基础 4
2.1、治疗目标与原则 4
2.2、新方法的科学依据 4
2.3、临床应用可行性分析 5
第3章、新治疗方法的技术路径 6
3.1、药物治疗优化策略 6
3.2、放腹水技术改进研究 6
3.3、生物疗法的应用探索 6
第4章、新方法的临床试验与效果评估 8
4.1、试验设计与实施过程 8
4.2、数据分析与结果解读 8
4.3、安全性与有效性评价 8
结 论 10
参考文献 11
