摘要
前列腺增生（BPH）是中老年男性常见疾病，严重影响患者生活质量，哌唑嗪作为一种α1-肾上腺素能受体拮抗剂，在治疗BPH中的应用逐渐受到关注本研究旨在评估哌唑嗪对男性前列腺增生的治疗效果及安全性，为临床用药提供依据研究采用随机双盲对照试验，选取200例BPH患者，分为哌唑嗪治疗组和安慰剂对照组，疗程为期12周通过国际前列腺症状评分（IPSS）、最大尿流率（Qmax）及残余尿量（PVR）等指标评价疗效，并记录不良反应结果表明，治疗组在改善IPSS、提高Qmax及降低PVR方面均显著优于对照组（P0.05），且起效迅速，未见严重不良反应发生本研究创新性地对比了不同剂量哌唑嗪的疗效差异，发现低剂量即可达到理想效果，进一步提升了其安全性研究表明，哌唑嗪可作为BPH的有效治疗药物，具有良好的临床应用前景关键词：前列腺增生；哌唑嗪；治疗效果；安全性；剂量差异
Efficacy and Safety Evaluation of Prazosin in the Treatment of Benign Prostatic Hyperplasia in Men
Abstract
Benign prostatic hyperplasia (BPH) is a common disease among middle-aged and elderly men, significantly affecting patients' quality of life. Prazosin, as an α1-adrenergic receptor antagonist, has gradually drawn attention in the treatment of BPH. This study aimed to evaluate the efficacy and safety of prazosin in male patients with BPH, providing evidence for clinical medication. A randomized double-blind controlled trial was conducted, involving 200 BPH patients who were divided into a prazosin treatment group and a placebo control group, with a treatment duration of 12 weeks. The therapeutic effects were assessed using the International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), post-void residual urine volume (PVR), and other indicators, while adverse reactions were also recorded. The results showed that the treatment group significantly outperformed the control group in improving IPSS, increasing Qmax, and reducing PVR (P0.05), with rapid onset of action and no severe adverse reactions observed. This study innovatively compared the efficacy differences of various doses of prazosin, revealing that low doses could achieve ideal effects, further enhancing its safety profile. The findings indicate that prazosin can serve as an effective treatment for BPH, demonstrating promising clinical application prospects.
Keywords: Prostate Hyperplasia; Prazosin; Treatment Effect; Safety; Dose Difference
目录
摘要 I
Abstract II
引言 1
1 哌唑嗪治疗机制与前列腺增生 1
1.1 哌唑嗪作用机理分析 1
1.2 前列腺增生病理基础 2
1.3 治疗机制的关联性研究 2
2 哌唑嗪治疗效果评估方法 3
2.1 疗效评价指标体系构建 3
2.2 临床试验设计与实施 3
2.3 数据分析方法与结果解读 4
3 哌唑嗪治疗的安全性分析 4
3.1 不良反应发生率统计 4
3.2 安全性影响因素探讨 4
3.3 风险管理与应对策略 5
4 哌唑嗪治疗的综合评价与优化建议 5
4.1 治疗效果与安全性对比分析 5
4.2 影响疗效的关键因素研究 6
4.3 改进方案与临床应用前景 6
结论 7
参考文献 8
致谢 9
