摘要
消化性溃疡出血是临床常见的急症之一，其治疗一直是医学研究的重点领域。本研究旨在探讨西咪替丁在消化性溃疡出血中的止血效果及其作用机制。通过随机对照试验，选取120例确诊为消化性溃疡出血的患者，分为实验组和对照组，实验组采用西咪替丁联合常规治疗，对照组仅接受常规治疗。研究结果显示，实验组患者的止血时间显著缩短，再出血率明显降低，且胃内pH值维持在较高水平的时间更长。此外，西咪替丁通过抑制组胺H2受体减少胃酸分泌，从而有效保护胃黏膜，促进溃疡愈合。与传统治疗方法相比，西咪替丁的应用不仅提高了止血成功率，还减少了并发症的发生。本研究创新性地验证了西咪替丁在消化性溃疡出血治疗中的独特优势，为临床提供了新的治疗思路和参考依据，具有重要的实践意义和应用价值。关键词：西咪替丁；消化性溃疡出血；止血效果；组胺H2受体；胃酸分泌
Efficacy of Cimetidine in Hemostasis for Bleeding Peptic Ulcer
Abstract
Gastrointestinal bleeding due to peptic ulcers is one of the common emergencies in clinical practice, and its treatment has remained a key focus in medical research. This study aimed to investigate the hemostatic efficacy and mechanism of cimetidine in the management of bleeding peptic ulcers. Through a randomized controlled trial, 120 patients diagnosed with bleeding peptic ulcers were selected and divided into an experimental group and a control group. The experimental group received cimetidine in combination with conventional therapy, while the control group underwent conventional therapy alone. The results demonstrated that the hemostasis time was significantly shortened in the experimental group, with a markedly reduced rebleeding rate, and the gastric pH was maintained at a higher level for a longer period. Furthermore, cimetidine effectively protected the gastric mucosa and promoted ulcer healing by inhibiting histamine H2 receptors and reducing gastric acid secretion. Compared with traditional treatment methods, the application of cimetidine not only improved the success rate of hemostasis but also decreased the occurrence of complications. This study innovatively validated the unique advantages of cimetidine in the treatment of bleeding peptic ulcers, providing new therapeutic insights and reference for clinical practice, with significant practical implications and application value.
Keywords: Cimetidine; Peptic Ulcer Bleeding; Hemostatic Effect; Histamine H2 Receptor; Gastric Acid Secretion
目录
摘要 I
Abstract II
引言 1
1 西咪替丁的药理机制研究 1
1.1 西咪替丁作用原理分析 1
1.2 抑制胃酸分泌的机制探讨 2
1.3 与止血效果的相关性研究 2
2 消化性溃疡出血的病理基础 2
2.1 溃疡出血的主要病因分析 2
2.2 出血对机体的影响评估 3
2.3 西咪替丁干预的理论依据 3
3 西咪替丁在止血中的临床应用 4
3.1 不同剂量的疗效对比研究 4
3.2 联合用药的效果评估分析 4
3.3 特殊人群的应用安全性探讨 5
4 西咪替丁止血效果的评价与展望 5
4.1 止血效果的临床数据总结 5
4.2 不良反应及局限性分析 6
4.3 未来研究方向与优化策略 6
结论 6
参考文献 8
致谢 9
