摘要
高胆固醇血症是动脉粥样硬化性心血管疾病的重要危险因素，降低血脂水平对预防和治疗动脉粥样硬化具有重要意义本研究旨在探讨瑞舒伐他汀对高胆固醇血症患者血脂水平及动脉粥样硬化的影响，采用随机双盲对照试验方法，选取120例高胆固醇血症患者，分为瑞舒伐他汀治疗组和安慰剂对照组，疗程为12个月检测两组患者治疗前后总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)水平以及颈动脉内膜中层厚度(IMT)变化结果显示，瑞舒伐他汀治疗组TC、LDL-C和TG水平显著降低，HDL-C水平有所升高，且颈动脉IMT明显减小，与对照组相比差异具有统计学意义(P0.05)该研究创新性地结合血脂指标与影像学参数评估瑞舒伐他汀的疗效，证实其不仅能有效调节血脂谱，还对延缓动脉粥样硬化进程具有积极作用，为临床用药提供了重要参考依据关键词：瑞舒伐他汀；高胆固醇血症；动脉粥样硬化；血脂水平；颈动脉IMT
Effects of Rosuvastatin on Lipid Profiles and Atherosclerosis in Patients with Hypercholesterolemia
Abstract
Hypercholesterolemia is a critical risk factor for atherosclerotic cardiovascular disease, and reducing lipid levels plays an important role in the prevention and treatment of atherosclerosis. This study aimed to investigate the effects of rosuvastatin on lipid profiles and atherosclerosis in patients with hypercholesterolemia using a randomized, double-blind, controlled trial design. A total of 120 patients with hypercholesterolemia were enrolled and randomly divided into a rosuvastatin treatment group and a placebo control group, with a treatment duration of 12 months. Levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), as well as changes in carotid intima-media thickness (IMT), were measured before and after treatment in both groups. The results showed that TC, LDL-C, and TG levels significantly decreased in the rosuvastatin treatment group, while HDL-C levels increased, and carotid IMT was markedly reduced compared to the control group, with statistically significant differences (P0.05). This study innovatively combined lipid parameters with imaging indicators to evaluate the efficacy of rosuvastatin, confirming its ability not only to effectively modulate the lipid profile but also to positively delay the progression of atherosclerosis, providing important reference evidence for clinical medication.
Keywords: Rosuvastatin; Hypercholesterolemia; Atherosclerosis; Lipid Levels; Carotid Intima-Media Thickness
目录
摘要 I
Abstract II
引言 1
1 瑞舒伐他汀的作用机制研究 1
1.1 他汀类药物的基本原理 1
1.2 瑞舒伐他汀的代谢过程分析 2
1.3 高胆固醇血症的靶点作用 2
2 血脂水平的改善效果评估 3
2.1 总胆固醇水平的变化分析 3
2.2 低密度脂蛋白胆固醇的调节 3
2.3 高密度脂蛋白胆固醇的影响研究 3
3 动脉粥样硬化的干预效果 4
3.1 炎症指标的改善情况 4
3.2 血管内皮功能的恢复研究 4
3.3 斑块稳定性与进展的评估 5
4 安全性与长期疗效分析 5
4.1 不良反应的发生率统计 5
4.2 长期用药的耐受性研究 6
4.3 综合疗效与风险的权衡 6
结论 7
参考文献 8
致谢 9
