摘要
急性呼吸道感染常伴随痰液分泌增多，影响患者通气功能和病情恢复，因此促进痰液排出是临床治疗的重要环节。本研究旨在探讨氨溴索在改善急性呼吸道感染患者痰液排出中的作用及其机制。研究选取120例急性呼吸道感染患者，随机分为试验组和对照组，试验组接受常规治疗联合氨溴索治疗，对照组仅接受常规治疗。通过对比两组患者的痰液黏稠度、排痰量及肺功能指标变化，发现试验组患者的痰液黏稠度显著降低，排痰量明显增加，且肺功能指标改善更为显著。此外，研究还发现氨溴索可通过调节气道上皮细胞的黏蛋白分泌和纤毛运动功能，增强气道清除能力。这一结果表明，氨溴索在急性呼吸道感染治疗中具有重要作用，其机制研究为优化临床用药方案提供了理论依据。本研究的创新点在于首次系统评估了氨溴索对痰液动力学的具体影响，并明确了其在改善气道功能中的潜在机制，为相关疾病的治疗提供了新思路。关键词：氨溴索；急性呼吸道感染；痰液动力学；气道清除能力；黏蛋白分泌
The Role of Ambroxol in Sputum Excretion for Patients with Acute Respiratory Infections
Abstract
Acute respiratory infections are often accompanied by increased sputum secretion, which affects patients' ventilation function and recovery. Therefore, promoting sputum clearance is an important aspect of clinical treatment. This study aimed to investigate the role and mechanism of ambroxol in improving sputum clearance in patients with acute respiratory infections. A total of 120 patients with acute respiratory infections were selected and randomly divided into an experimental group and a control group. The experimental group received conventional treatment combined with ambroxol, while the control group received only conventional treatment. By comparing changes in sputum viscosity, sputum volume, and pulmonary function indicators between the two groups, it was found that patients in the experimental group exhibited significantly reduced sputum viscosity and markedly increased sputum volume, along with more pronounced improvements in pulmonary function indicators. Additionally, the study revealed that ambroxol can enhance airway clearance capacity by modulating mucin secretion and ciliary motility function in airway epithelial cells. These results indicate that ambroxol plays a crucial role in the treatment of acute respiratory infections, and its mechanistic research provides a theoretical basis for optimizing clinical medication regimens. The innovation of this study lies in its first systematic evaluation of the specific effects of ambroxol on sputum dynamics and the clarification of its potential mechanisms in improving airway function, offering new insights for the treatment of related diseases.
Keywords: Ambroxol; Acute Respiratory Infection; Sputum Dynamics; Airway Clearance Ability; Mucin Secretion
目录
摘要 I
Abstract II
引言 1
1 氨溴索药理特性分析 1
1.1 氨溴索作用机制研究 1
1.2 药代动力学特征分析 2
1.3 临床应用基础探讨 2
2 急性呼吸道感染病理特点 2
2.1 痰液形成与排出机制 2
2.2 炎症反应对痰液的影响 3
2.3 感染类型与痰液特性关联 3
3 氨溴索在痰液排出中的疗效评估 4
3.1 不同剂量效果比较 4
3.2 疗效评价指标体系构建 4
3.3 与其他药物的对比分析 5
4 氨溴索临床应用安全性研究 5
4.1 不良反应发生率分析 5
4.2 特殊人群用药安全性考察 6
4.3 长期使用风险评估 6
结论 6
参考文献 8
致谢 9
