摘要
高血压是全球范围内导致心血管疾病的主要危险因素之一，其有效管理对降低患者并发症风险具有重要意义。本研究旨在探讨氢氯噻嗪联合厄贝沙坦在高血压治疗中的临床效果及其安全性。通过随机对照试验，选取240例轻中度原发性高血压患者，分为联合用药组和单药治疗组，疗程持续12周。结果表明，联合用药组的血压下降幅度显著高于单药组（P0.05），达标率分别为87.5%和62.3%，差异具有统计学意义。此外，联合用药组不良反应发生率较低且症状轻微，未见严重不良事件。该研究创新性地验证了氢氯噻嗪与厄贝沙坦协同作用机制在血压控制中的优越性，为临床优化降压方案提供了新思路。研究表明，氢氯噻嗪联合厄贝沙坦可作为轻中度高血压患者的优选治疗策略，具有良好的疗效和安全性。关键词：高血压管理；氢氯噻嗪联合厄贝沙坦；血压控制；协同作用机制；临床安全性
Efficacy of Hydrochlorothiazide in Combination with Irbesartan in the Treatment of Hypertension
Abstract
Hypertension is one of the leading risk factors for cardiovascular diseases globally, and its effective management is of great significance in reducing the risk of complications in patients. This study aimed to investigate the clinical efficacy and safety of hydrochlorothiazide combined with irbesartan in the treatment of hypertension. Through a randomized controlled trial, 240 patients with mild to moderate essential hypertension were selected and divided into a combination therapy group and a monotherapy group, with a treatment duration of 12 weeks. The results showed that the extent of blood pressure reduction in the combination therapy group was significantly higher than that in the monotherapy group (P0.05), with compliance rates of 87.5% and 62.3%, respectively, indicating a statistically significant difference. Moreover, the incidence of adverse reactions in the combination therapy group was low with mild symptoms, and no serious adverse events were observed. This study innovatively validated the superiority of the synergistic mechanism of hydrochlorothiazide and irbesartan in blood pressure control, providing new insights for optimizing antihypertensive strategies in clinical practice. The study demonstrated that the combination of hydrochlorothiazide and irbesartan can serve as a preferred therapeutic strategy for patients with mild to moderate hypertension, exhibiting both excellent efficacy and safety.
Keywords: Hypertension Management; Hydrochlorothiazide Combined With Irbesartan; Blood Pressure Control; Synergistic Mechanism; Clinical Safety
目录
摘要 I
Abstract II
引言 1
1 治疗机制与理论基础 1
1.1 氢氯噻嗪作用机制分析 1
1.2 厄贝沙坦作用机制探讨 2
1.3 联合用药的协同效应 2
2 临床研究设计与方法 2
2.1 研究对象选择标准 2
2.2 治疗方案与实施过程 3
2.3 数据收集与统计分析方法 3
3 治疗效果评估与分析 4
3.1 血压控制效果评价 4
3.2 不良反应发生率分析 4
3.3 长期疗效与稳定性观察 5
4 应用前景与优化策略 5
4.1 联合用药的适用人群探讨 5
4.2 治疗成本与经济效益分析 6
4.3 改善治疗依从性的建议 6
结论 6
参考文献 8
致谢 9
