摘要
产后出血是全球范围内导致孕产妇死亡的主要原因之一，其有效防治仍是临床亟待解决的重要问题。本研究旨在探讨氨甲环酸在产后出血中的止血效果及安全性，为临床应用提供依据。研究选取2018年至2022年间某三甲医院收治的300例产后出血患者，随机分为试验组（使用氨甲环酸）和对照组（常规治疗），对比两组患者的出血量、止血时间及不良反应发生率。结果显示，试验组平均出血量显著低于对照组（P0.05），止血时间明显缩短（P0.01），且未观察到严重不良反应。进一步分析表明，氨甲环酸通过抑制纤维蛋白溶解，有效减少产后出血的发生和发展，同时具有良好的安全性。本研究创新性地结合大样本数据与详细指标监测，证实了氨甲环酸在产后出血管理中的重要价值，为优化临床治疗策略提供了新思路。关键词：产后出血；氨甲环酸；止血效果；安全性；纤维蛋白溶解
Efficacy and Safety of Tranexamic Acid in Postpartum Hemorrhage Control
Abstract
Postpartum hemorrhage is one of the leading causes of maternal mortality worldwide, and its effective prevention and treatment remain critical issues to be addressed in clinical practice. This study aimed to investigate the hemostatic efficacy and safety of tranexamic acid in postpartum hemorrhage, providing evidence for its clinical application. A total of 300 patients with postpartum hemorrhage treated at a tertiary hospital between 2018 and 2022 were randomly divided into a trial group (receiving tranexamic acid) and a control group (undergoing conventional treatment). The blood loss, hemostasis time, and incidence of adverse reactions were compared between the two groups. The results showed that the average blood loss in the trial group was significantly lower than that in the control group (P0.05), the hemostasis time was markedly reduced (P0.01), and no severe adverse reactions were observed. Further analysis indicated that tranexamic acid effectively reduced the occurrence and progression of postpartum hemorrhage by inhibiting fibrinolysis and demonstrated good safety. Innovatively combining large-scale sample data with detailed indicator monitoring, this study confirmed the significant value of tranexamic acid in the management of postpartum hemorrhage and provided new insights for optimizing clinical treatment strategies.
Keywords: Postpartum Hemorrhage; Tranexamic Acid; Hemostatic Effect; Safety; Fibrinolysis
目录
摘要 I
Abstract II
引言 1
1 氨甲环酸的作用机制研究 1
1.1 氨甲环酸的药理特性分析 1
1.2 凝血功能调控中的作用机制 2
1.3 产后出血相关病理生理关联 2
2 氨甲环酸在产后出血中的应用现状 3
2.1 国内外临床应用概况 3
2.2 不同剂量方案的效果比较 3
2.3 特殊人群用药适应性探讨 3
3 止血效果的临床评估与分析 4
3.1 止血效果的关键指标定义 4
3.2 临床试验数据的统计分析方法 4
3.3 止血效果的影响因素探讨 5
4 氨甲环酸的安全性评价与风险控制 5
4.1 常见不良反应的发生机制 5
4.2 安全性监测指标的选择与意义 6
4.3 风险管理策略与临床建议 6
结论 7
参考文献 8
致谢 9
