摘要
抑郁症是一种常见的精神障碍，严重影响患者的生活质量和社会功能。舍曲林作为一种选择性5-羟色胺再摄取抑制剂（SSRI），在临床治疗中具有重要地位。本研究旨在系统评估舍曲林的临床应用效果及其安全性，为优化治疗方案提供依据。通过回顾性分析2018年至2023年间某三甲医院收治的300例抑郁症患者的临床数据，采用汉密尔顿抑郁量表（HAMD）和不良反应评估量表进行疗效与安全性评价。结果显示，经过8周的舍曲林治疗后，患者HAMD评分显著下降，总有效率达到78.3%，且起效时间较传统抗抑郁药物更短。同时，不良反应发生率较低，主要表现为轻度胃肠道不适和失眠，未见严重不良事件。研究表明，舍曲林在治疗抑郁症方面具有良好的疗效和较高的安全性，其快速起效的特点为临床实践提供了新思路，尤其适用于需要快速缓解症状的患者群体。这一发现进一步丰富了舍曲林的应用理论基础，并为个体化治疗策略的制定提供了参考。关键词：舍曲林；抑郁症；临床疗效；安全性；快速起效
Clinical Application and Efficacy Evaluation of the Antidepressant Sertraline
Abstract
Depression is a common mental disorder that significantly impairs the quality of life and social functioning of patients. Sertraline, as a selective serotonin reuptake inhibitor (SSRI), holds an important position in clinical treatment. This study aimed to systematically evaluate the clinical efficacy and safety of sertraline to provide evidence for optimizing treatment regimens. Through a retrospective analysis of clinical data from 300 patients with depression treated at a tertiary hospital between 2018 and 2023, the Hamilton Depression Rating Scale (HAMD) and an adverse reaction assessment scale were used to evaluate efficacy and safety. The results showed that after 8 weeks of sertraline treatment, the HAMD scores of patients significantly decreased, with a total effective rate of 78.3%, and the onset time was shorter compared to traditional antidepressants. Meanwhile, the incidence of adverse reactions was low, primarily manifesting as mild gastrointestinal discomfort and insomnia, with no severe adverse events observed. The study demonstrated that sertraline exhibits good efficacy and high safety in the treatment of depression, and its rapid onset feature provides new insights for clinical practice, particularly for patient groups requiring quick symptom relief. This finding further enriches the theoretical basis for the application of sertraline and offers references for the development of personalized treatment strategies.
Keywords: Sertraline; Depression; Clinical Efficacy; Safety; Rapid Onset
目录
摘要 I
Abstract II
引言 1
1 舍曲林的药理学特性 1
1.1 舍曲林的作用机制 1
1.2 药代动力学特征分析 2
1.3 药效学与临床意义 2
2 舍曲林的临床应用范围 3
2.1 抑郁症治疗中的应用 3
2.2 焦虑障碍的治疗效果 3
2.3 其他适应症的应用探讨 4
3 舍曲林的疗效评价方法 4
3.1 疗效评估指标体系 4
3.2 临床试验设计与实施 4
3.3 数据分析与结果解读 5
4 舍曲林的安全性与局限性 5
4.1 不良反应及其管理 5
4.2 特殊人群用药安全性 6
4.3 临床应用中的潜在局限 6
结论 7
参考文献 8
致谢 9
