摘 要
中药药性与归经理论作为中医理论体系的重要组成部分，在中医药学中占据核心地位，其内涵丰富且复杂。随着现代科学技术的发展，对传统中医理论进行科学解析成为必然趋势。本研究旨在运用多学科交叉方法，从分子生物学、系统生物学及网络药理学等角度深入探讨中药药性与归经的科学本质。通过构建中药活性成分-靶点-通路网络模型，结合临床数据挖掘与分析，揭示了药性与归经之间内在联系及其作用机制。研究发现，不同归经药物具有特定的生物靶向性，其作用模式呈现模块化特征，这为理解中药复方配伍规律提供了新视角。同时，基于代谢组学技术平台，进一步阐明了药性寒热温凉在体内产生的差异化代谢响应，证明了药性物质基础的存在形式及其动态变化过程。本研究不仅为中药药性与归经理论建立了较为系统的科学解释框架，也为中药现代化研究开辟了新的路径，有助于推动中医药走向世界舞台，促进传统医学与现代科学深度融合，为人类健康事业作出更大贡献。
关键词：中药药性与归经；分子生物学；网络药理学；生物靶向性；代谢组学技术平台
Abstract
The theory of medicinal properties and meridian tropism in traditional Chinese medicine (TCM) is a critical component of the TCM theoretical system, occupying a central position in the field of traditional Chinese pharmacology. Its connotations are rich and complex. With the advancement of modern science and technology, scientifically elucidating traditional TCM theories has become an inevitable trend. This study aims to explore the scientific essence of medicinal properties and meridian tropism through interdisciplinary approaches, incorporating perspectives from molecular biology, systems biology, and network pharmacology. By constructing a network model linking active ingredients of Chinese herbs with their targets and pathways, combined with clinical data mining and analysis, this research reveals the intrinsic connections and mechanisms between medicinal properties and meridian tropism. The findings indicate that drugs with different meridian tropisms exhibit specific biological target orientation, characterized by modular patterns of action, providing new insights into the compatibility rules of TCM compound presc riptions. Furthermore, based on me tabolomics technology platforms, this study elucidates the differential me tabolic responses elicited by the four natures (cold, hot, warm, cool) of medicinal properties within the body, demonstrating the existence and dynamic changes of the material basis of medicinal properties. This research not only establishes a relatively systematic scientific explanation fr amework for the theory of medicinal properties and meridian tropism but also opens up new avenues for the modernization of Chinese medicine, facilitating the integration of traditional medicine with modern science and contributing to global health.
Keywords：Traditional Chinese Medicine Properties And Meridian Tropism；Molecular Biology；Network Pharmacology；Biological Targeting；me tabolomics Technology Platform
目 录
摘 要 I
Abstract II
引 言 1
第一章 中药药性理论的科学基础 2
1.1 药性的定义与分类 2
1.2 药性作用机制研究 2
1.3 药性与物质基础关联 3
第二章 归经理论的现代解析 4
2.1 归经概念的历史演变 4
2.2 归经的生理学依据 4
2.3 归经的分子生物学解释 5
第三章 药性与归经的相互关系 6
3.1 药性对归经的影响 6
3.2 归经对药性表达的作用 6
3.3 二者协同作用机制 7
第四章 药性归经理论的应用与发展 8
4.1 在临床治疗中的应用 8
4.2 对新药研发的指导意义 8
4.3 理论发展的未来方向 9
结 论 10
参考文献 11
致 谢 12
