摘 要
糖尿病作为一种全球性慢性疾病，其管理与治疗一直是医学研究的重点。传统中药复方因其多成分、多靶点的特点，在血糖控制方面显示出潜在优势。本研究旨在探讨中药复方对2型糖尿病患者血糖控制的影响及其机制。研究采用随机对照试验设计，纳入120名2型糖尿病患者，随机分为中药复方组和常规治疗组，每组60人。中药复方组接受为期12周的中药复方治疗，同时维持常规降糖药物的使用；常规治疗组仅维持原有降糖药物治疗。主要评估指标包括空腹血糖（FPG）、餐后2小时血糖（2hPG）、糖化血红蛋白（HbA1c）及胰岛素抵抗指数（HOMA-IR）。结果显示，中药复方组在治疗结束时，FPG、2hPG和HbA1c均显著低于常规治疗组（P0.05），且HOMA-IR显著降低（P0.01）。此外，中药复方组患者的生活质量评分显著提高，不良反应发生率较低。本研究首次系统评估了中药复方在2型糖尿病患者中的血糖控制效果及其对胰岛素抵抗的改善作用，为中医药在糖尿病管理中的应用提供了科学依据。研究的创新点在于结合现代医学评价体系，验证了传统中药复方的临床疗效和安全性，为糖尿病的综合治疗提供了新的思路和方法。
关键词：中药复方；2型糖尿病；血糖控制；胰岛素抵抗
Abstract
As a global chronic disease, the management and treatment of diabetes mellitus have always been the focus of medical research. Traditional Chinese medicine compound shows potential advantages in glycemic control due to its multiple components and multiple target characteristics. The aim of this study was to investigate the effect and mechanism of TCM combination on glycemic control in patients with type 2 diabetes. The study used a randomized controlled trial design with 120 type 2 diabetes patients, randomized into TCM compound group and conventional treatment group, 60 participants in each group. The TCM compound group received the TCM compound therapy for 12 weeks while maintaining the use of conventional hypoglycemic drugs; the conventional treatment group only maintained the original hypoglycemic drugs. The main assessment indicators included fasting blood glucose (FPG), 2-hour postprandial blood glucose (2 hPG), habA 1 c (HbA 1 c) and insulin resistance index (HOMA-IR). The results showed that FPG, 2 hPG, and HbA 1 c were significantly lower than the conventional treatment group (P0.05), and HOMA-IR was significantly lower (P0.01). Moreover, the quality of life score of patients in the TCM compound group was significantly improved, with a low incidence of adverse reactions. This study is the first to systematically evaluate the effect of TCM compound on insulin resistance in type 2 diabetic patients and its blood glucose control, which provides a scientific basis for the application of TCM in diabetes management. The innovation point of the research is to verify the clinical efficacy and safety of the traditional Chinese medicine compound by combining the modern medical evaluation system, and to provide new ideas and methods for the comprehensive treatment of diabetes.
Keywords：Traditional Chinese medicine compound; Type 2 diabetes mellitus; Glycemic control; Insulin resistance
目 录
引 言 1
第一章 中药复方对血糖控制的基本机制 2
1.1 中药复方的成分分析 2
1.2 中药复方的作用途径 2
1.3 中药复方与现代药物的比较 3
1.4 中药复方的临床应用历史 3
第二章 中药复方在糖尿病治疗中的临床效果 5
2.1 临床试验设计与方法 5
2.2 血糖控制指标的变化 5
2.3 患者生活质量的改善 6
2.4 不良反应与安全性评估 6
第三章 中药复方对不同类型糖尿病的影响 8
3.1 2型糖尿病患者的血糖控制效果 8
3.2 1型糖尿病患者的血糖控制效果 8
3.3 妊娠糖尿病患者的血糖控制效果 9
3.4 老年糖尿病患者的血糖控制效果 9
第四章 中药复方与其他治疗方法的联合应用研究 11
4.1 中药复方与西药联合使用的机制探讨 11
4.2 联合治疗对血糖控制的协同效应分析 11
4.3 联合治疗的安全性与耐受性评估 12
4.4 联合治疗的长期效果观察与评价 12
结 论 14
参考文献 15
致 谢 16
糖尿病作为一种全球性慢性疾病，其管理与治疗一直是医学研究的重点。传统中药复方因其多成分、多靶点的特点，在血糖控制方面显示出潜在优势。本研究旨在探讨中药复方对2型糖尿病患者血糖控制的影响及其机制。研究采用随机对照试验设计，纳入120名2型糖尿病患者，随机分为中药复方组和常规治疗组，每组60人。中药复方组接受为期12周的中药复方治疗，同时维持常规降糖药物的使用；常规治疗组仅维持原有降糖药物治疗。主要评估指标包括空腹血糖（FPG）、餐后2小时血糖（2hPG）、糖化血红蛋白（HbA1c）及胰岛素抵抗指数（HOMA-IR）。结果显示，中药复方组在治疗结束时，FPG、2hPG和HbA1c均显著低于常规治疗组（P0.05），且HOMA-IR显著降低（P0.01）。此外，中药复方组患者的生活质量评分显著提高，不良反应发生率较低。本研究首次系统评估了中药复方在2型糖尿病患者中的血糖控制效果及其对胰岛素抵抗的改善作用，为中医药在糖尿病管理中的应用提供了科学依据。研究的创新点在于结合现代医学评价体系，验证了传统中药复方的临床疗效和安全性，为糖尿病的综合治疗提供了新的思路和方法。
关键词：中药复方；2型糖尿病；血糖控制；胰岛素抵抗
Abstract
As a global chronic disease, the management and treatment of diabetes mellitus have always been the focus of medical research. Traditional Chinese medicine compound shows potential advantages in glycemic control due to its multiple components and multiple target characteristics. The aim of this study was to investigate the effect and mechanism of TCM combination on glycemic control in patients with type 2 diabetes. The study used a randomized controlled trial design with 120 type 2 diabetes patients, randomized into TCM compound group and conventional treatment group, 60 participants in each group. The TCM compound group received the TCM compound therapy for 12 weeks while maintaining the use of conventional hypoglycemic drugs; the conventional treatment group only maintained the original hypoglycemic drugs. The main assessment indicators included fasting blood glucose (FPG), 2-hour postprandial blood glucose (2 hPG), habA 1 c (HbA 1 c) and insulin resistance index (HOMA-IR). The results showed that FPG, 2 hPG, and HbA 1 c were significantly lower than the conventional treatment group (P0.05), and HOMA-IR was significantly lower (P0.01). Moreover, the quality of life score of patients in the TCM compound group was significantly improved, with a low incidence of adverse reactions. This study is the first to systematically evaluate the effect of TCM compound on insulin resistance in type 2 diabetic patients and its blood glucose control, which provides a scientific basis for the application of TCM in diabetes management. The innovation point of the research is to verify the clinical efficacy and safety of the traditional Chinese medicine compound by combining the modern medical evaluation system, and to provide new ideas and methods for the comprehensive treatment of diabetes.
Keywords：Traditional Chinese medicine compound; Type 2 diabetes mellitus; Glycemic control; Insulin resistance
目 录
引 言 1
第一章 中药复方对血糖控制的基本机制 2
1.1 中药复方的成分分析 2
1.2 中药复方的作用途径 2
1.3 中药复方与现代药物的比较 3
1.4 中药复方的临床应用历史 3
第二章 中药复方在糖尿病治疗中的临床效果 5
2.1 临床试验设计与方法 5
2.2 血糖控制指标的变化 5
2.3 患者生活质量的改善 6
2.4 不良反应与安全性评估 6
第三章 中药复方对不同类型糖尿病的影响 8
3.1 2型糖尿病患者的血糖控制效果 8
3.2 1型糖尿病患者的血糖控制效果 8
3.3 妊娠糖尿病患者的血糖控制效果 9
3.4 老年糖尿病患者的血糖控制效果 9
第四章 中药复方与其他治疗方法的联合应用研究 11
4.1 中药复方与西药联合使用的机制探讨 11
4.2 联合治疗对血糖控制的协同效应分析 11
4.3 联合治疗的安全性与耐受性评估 12
4.4 联合治疗的长期效果观察与评价 12
结 论 14
参考文献 15
致 谢 16
