摘 要
慢性心力衰竭是心血管疾病终末阶段，具有高发病率、高死亡率特点，现代医学虽取得一定进展但仍存在诸多局限，中药复方在改善症状、提高生活质量方面展现出独特优势。本研究旨在探讨中药复方治疗慢性心力衰竭的临床疗效及安全性，为中医药治疗提供循证依据。选取某院2018年1月至2021年1月收治的120例慢性心力衰竭患者作为研究对象，随机分为观察组和对照组各60例，对照组采用常规西医治疗方案，观察组在对照组基础上加用自拟中药复方汤剂，疗程均为3个月。通过对比两组患者治疗前后的心功能指标（LVEF、LVEDD）、BNP水平、中医证候积分、6分钟步行距离以及不良反应发生情况等多维度评估临床效果。结果显示，观察组患者心功能指标改善程度优于对照组，LVEF升高更明显，LVEDD降低幅度更大，BNP水平下降显著，中医证候积分减少更多，6分钟步行距离延长，差异均有统计学意义（P0.05）。且观察组未见明显不良反应增加。本研究创新性地将传统中医药理论与现代医学评价体系相结合，证实了中药复方在慢性心力衰竭治疗中可有效改善心功能，减轻症状，提高运动耐量，安全性良好，为慢性心力衰竭的综合治疗提供了新思路，拓展了中医药的应用领域，对促进中医药现代化发展具有重要意义。
关键词：慢性心力衰竭；中药复方；临床疗效；心功能指标；安全性
Abstract
Chronic heart failure, as the terminal stage of cardiovascular diseases, is characterized by high incidence and mortality. Although modern medicine has made certain progress in its treatment, many limitations still exist. Traditional Chinese medicine (TCM) compound presc riptions have demonstrated unique advantages in symptom improvement and quality of life enhancement. This study aims to investigate the clinical efficacy and safety of TCM compound presc riptions in treating chronic heart failure, providing evidence-based support for TCM therapy. A total of 120 patients with chronic heart failure admitted to a hospital from January 2018 to January 2021 were selected and randomly divided into an observation group and a control group, each consisting of 60 cases. The control group received conventional Western medicine treatment, while the observation group was additionally administered a self-formulated TCM compound decoction on the basis of the control group’s regimen; both groups underwent a three-month treatment course. Multiple dimensions were used to evaluate the clinical effects by comparing pre- and post-treatment cardiac function indicators (LVEF, LVEDD), BNP levels, TCM syndrome scores, six-minute walking distance, and adverse reaction occurrences between the two groups. The results showed that the degree of cardiac function indicator improvement in the observation group was superior to that in the control group, with more significant increases in LVEF, greater reductions in LVEDD, marked decreases in BNP levels, larger reductions in TCM syndrome scores, and longer six-minute walking distances, all of which exhibited statistically significant differences (P0.05). Moreover, no obvious increase in adverse reactions was observed in the observation group. This study innovatively combines traditional TCM theory with modern medical evaluation systems, confirming that TCM compound presc riptions can effectively improve cardiac function, alleviate symptoms, enhance exercise tolerance, and ensure good safety in the treatment of chronic heart failure. It provides new ideas for comprehensive treatment of chronic heart failure, expands the application fields of TCM, and holds significant importance for promoting the modernization development of TCM.
Keywords：Chronic Heart Failure；Traditional Chinese Medicine Compound；Clinical Efficacy；Cardiac Function Indices；Safety
目 录
摘 要 I
Abstract II
引 言 1
第一章 慢性心力衰竭的现状与挑战 2
1.1 慢性心力衰竭流行病学 2
1.2 西医治疗局限性分析 2
1.3 中医药介入的必要性 3
第二章 中药复方治疗方案设计 5
2.1 方剂组成与配伍原理 5
2.2 作用机制研究进展 5
2.3 疗程安排与用药指导 6
第三章 临床观察方法与实施 8
3.1 研究对象选择标准 8
3.2 观察指标体系建立 8
3.3 数据收集与质量控制 9
第四章 治疗效果评估与分析 11
4.1 短期疗效评价结果 11
4.2 长期随访观察总结 11
4.3 不良反应监测记录 12
结 论 13
参考文献 14
致 谢 15
