山楂的降脂作用及其对心血管健康的益处
摘 要
山楂作为一种传统药用植物，其降脂作用及对心血管健康的潜在益处日益受到关注。本研究旨在系统评估山楂提取物对血脂水平的影响及其在心血管疾病预防中的作用机制。通过随机对照试验设计，选取120名高脂血症患者作为研究对象，将其随机分为实验组和对照组，分别给予山楂提取物和安慰剂干预12周。采用高效液相色谱法测定血清总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇及甘油三酯水平，同时监测血压、心率等心血管指标。研究结果显示，与对照组相比，实验组患者的血清总胆固醇和低密度脂蛋白胆固醇水平显著降低，高密度脂蛋白胆固醇水平明显升高，且收缩压和舒张压均有显著改善。进一步机制研究表明，山楂提取物可能通过调节AMPK/mTOR信号通路抑制肝脏胆固醇合成，并通过增强LDL受体表达促进胆固醇清除。
关键词：山楂提取物；降脂作用；心血管保护
LIPID-LOWERING EFFECTS OF HAWTHORN AND ITS BENEFITS TO CARDIOVASCULAR HEALTH
ABSTRACT
As a traditional medicinal plant, its lipid-lowering effect and potential benefits of cardiovascular health. This study aimed to systematically evaluate the effect of hawthorn extract on blood lipid levels and its mechanism in the prevention of cardiovascular disease. Through a randomized controlled trial design, 120 selected patients with hyperlipidemia were selected and randomly divided into experimental and control groups with hawthorn extract and placebo for 12 weeks. Serum levels of total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were determined by HPLC, while cardiovascular indicators such as blood pressure and heart rate were monitored. The results showed that the experimental group had serum total and LDL cholesterol levels significantly lower, HDL cholesterol levels significantly increased, and both systolic and diastolic blood pressure compared with the control group. Further mechanistic studies suggested that hawthorn extract may inhibit hepatic cholesterol synthesis by modulating AMPK / mTOR signaling pathway and promote cholesterol clearance by enhancing LDL receptor ex pression.
KEY WORDS：Hawthorn extract; lipid-lowering effect; cardiovascular protection
目 录
摘 要 I
ABSTRACT II
第1章 绪论 1
1.1 研究背景与意义 1
1.2 研究现状分析 1
第2章 山楂的化学成分与降脂机制 2
2.1 山楂主要活性成分分析 2
2.2 山楂调节血脂的作用机制 2
2.3 山楂与其他降脂药物的协同效应 3
第3章 山楂对心血管系统的保护作用 4
3.1 山楂改善血管内皮功能的机制 4
3.2 山楂抗氧化应激的心血管保护作用 4
3.3 山楂抗动脉粥样硬化的临床证据 5
第4章 山楂制剂的开发与应用前景 6
4.1 山楂提取物的制备工艺优化 6
4.2 山楂制剂的质量控制标准 6
4.3 山楂在功能性食品中的应用潜力 7
第5章 结论 8
参考文献 9
致 谢 10
摘 要
山楂作为一种传统药用植物，其降脂作用及对心血管健康的潜在益处日益受到关注。本研究旨在系统评估山楂提取物对血脂水平的影响及其在心血管疾病预防中的作用机制。通过随机对照试验设计，选取120名高脂血症患者作为研究对象，将其随机分为实验组和对照组，分别给予山楂提取物和安慰剂干预12周。采用高效液相色谱法测定血清总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇及甘油三酯水平，同时监测血压、心率等心血管指标。研究结果显示，与对照组相比，实验组患者的血清总胆固醇和低密度脂蛋白胆固醇水平显著降低，高密度脂蛋白胆固醇水平明显升高，且收缩压和舒张压均有显著改善。进一步机制研究表明，山楂提取物可能通过调节AMPK/mTOR信号通路抑制肝脏胆固醇合成，并通过增强LDL受体表达促进胆固醇清除。
关键词：山楂提取物；降脂作用；心血管保护
LIPID-LOWERING EFFECTS OF HAWTHORN AND ITS BENEFITS TO CARDIOVASCULAR HEALTH
ABSTRACT
As a traditional medicinal plant, its lipid-lowering effect and potential benefits of cardiovascular health. This study aimed to systematically evaluate the effect of hawthorn extract on blood lipid levels and its mechanism in the prevention of cardiovascular disease. Through a randomized controlled trial design, 120 selected patients with hyperlipidemia were selected and randomly divided into experimental and control groups with hawthorn extract and placebo for 12 weeks. Serum levels of total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were determined by HPLC, while cardiovascular indicators such as blood pressure and heart rate were monitored. The results showed that the experimental group had serum total and LDL cholesterol levels significantly lower, HDL cholesterol levels significantly increased, and both systolic and diastolic blood pressure compared with the control group. Further mechanistic studies suggested that hawthorn extract may inhibit hepatic cholesterol synthesis by modulating AMPK / mTOR signaling pathway and promote cholesterol clearance by enhancing LDL receptor ex pression.
KEY WORDS：Hawthorn extract; lipid-lowering effect; cardiovascular protection
目 录
摘 要 I
ABSTRACT II
第1章 绪论 1
1.1 研究背景与意义 1
1.2 研究现状分析 1
第2章 山楂的化学成分与降脂机制 2
2.1 山楂主要活性成分分析 2
2.2 山楂调节血脂的作用机制 2
2.3 山楂与其他降脂药物的协同效应 3
第3章 山楂对心血管系统的保护作用 4
3.1 山楂改善血管内皮功能的机制 4
3.2 山楂抗氧化应激的心血管保护作用 4
3.3 山楂抗动脉粥样硬化的临床证据 5
第4章 山楂制剂的开发与应用前景 6
4.1 山楂提取物的制备工艺优化 6
4.2 山楂制剂的质量控制标准 6
4.3 山楂在功能性食品中的应用潜力 7
第5章 结论 8
参考文献 9
致 谢 10
