摘要
连续流动微反应器作为一种新兴的化学合成技术平台，近年来在精细化学品领域展现出显著优势。传统批量反应存在传质效率低、温度控制困难及安全性不足等问题，而微反应器凭借其微尺度结构特性，在高效传质与换热、精确过程控制以及本质安全等方面具有突出表现。本研究旨在系统分析连续流动微反应器在精细化学品合成中的技术优势，并通过对比实验验证其在反应效率、产物选择性及工艺放大方面的潜力。研究选取了典型精细化学品合成反应为案例，采用连续流动微反应器进行工艺优化，同时结合计算流体力学模拟方法探究反应器内部流场与反应动力学特性。结果表明，连续流动微反应器可显著提高反应速率和目标产物收率，同时有效降低副反应发生概率。此外，该技术在工艺放大的过程中表现出良好的可扩展性和稳定性，避免了传统批量反应器中常见的放大效应问题。本研究的创新点在于将微反应器技术与精细化学品合成需求紧密结合，提出了一种基于连续流动工艺的高效绿色合成策略，为推动精细化工行业向智能化、绿色化方向发展提供了重要参考。
关键词：连续流动微反应器；精细化学品合成；反应效率；工艺放大；绿色合成策略
Abstract
Continuous-flow microreactors, as an emerging chemical synthesis technology platform, have demonstrated significant advantages in the field of fine chemicals in recent years. Traditional batch reactions are often plagued by issues such as low mass transfer efficiency, difficulties in temperature control, and insufficient safety, whereas microreactors, leveraging their microscale structural characteristics, exhibit superior performance in efficient mass transfer and heat exchange, precise process control, and inherent safety. This study aims to systematically analyze the technical advantages of continuous-flow microreactors in fine chemical synthesis and validate their potential in reaction efficiency, product selectivity, and process scale-up through comparative experiments. A typical fine chemical synthesis reaction was selected as a case study, with process optimization achieved using a continuous-flow microreactor. Computational fluid dynamics simulation methods were also employed to investigate the internal flow field and reaction kinetics characteristics of the reactor. The results indicate that continuous-flow microreactors can significantly enhance reaction rates and target product yields while effectively reducing the probability of side reactions. Moreover, this technology exhibits excellent scalability and stability during process scale-up, avoiding the common scale-up effects encountered in traditional batch reactors. The innovation of this study lies in the close integration of microreactor technology with the specific requirements of fine chemical synthesis, proposing an efficient and green synthetic strategy based on continuous-flow processes. This provides crucial reference for advancing the fine chemical industry towards a more intelligent and sustainable direction.
Keywords：Continuous Flow Microreactor; Fine Chemicals Synthesis; Reaction Efficiency; Process Scale-Up; Green Synthesis Strategy
目 录
摘要 I
Abstract II
一、绪论 1
(一) 研究背景与意义 1
(二) 国内外研究现状分析 1
(三) 本文研究方法概述 2
二、微反应器技术的基本原理与优势 2
(一) 连续流动微反应器的工作机制 2
(二) 微通道设计对反应效率的影响 3
(三) 微反应器在精细化学品合成中的核心优势 3
三、安全性与可控性优势分析 4
(一) 微反应器的高安全性特点 4
(二) 反应条件精确控制的能力 4
(三) 在危险化学反应中的应用实例 5
四、高效性与经济性优势探讨 5
(一) 提升反应速率与选择性 5
(二) 资源与能源消耗的优化 6
(三) 工业化应用的经济效益评估 6
结 论 8
参考文献 9
