摘要
随着全球对环境保护和可持续发展的日益关注，制药工程领域迫切需要开发绿色生产工艺以减少环境污染并提高资源利用效率。本研究旨在探索并优化制药过程中绿色化学原则的应用，通过设计新型催化剂、改进反应路径以及采用可再生原料，实现高效低污染的药物生产。研究采用了多学科交叉方法，结合计算化学模拟与实验验证，系统评估了不同工艺条件下的环境影响和经济可行性。结果表明，通过引入生物基溶剂和选择性催化剂，显著降低了传统工艺中的废弃物排放，并提高了目标产物的收率和纯度。此外，研究还提出了一种基于生命周期分析的评价体系，用于量化绿色工艺的综合效益。本研究的创新点在于首次将机器学习算法应用于绿色工艺参数优化，大幅缩短了研发周期并提升了工艺稳定性。主要贡献体现在为制药行业提供了可行的绿色转型方案，同时为其他化工领域的可持续发展提供了借鉴意义。研究成果有望推动制药工程向更加环保和经济的方向迈进。
关键词：绿色化学；制药工程；生物基溶剂；机器学习优化；生命周期分析
Abstract
With growing global attention to environmental protection and sustainable development, the pharmaceutical engineering field urgently requires the development of green production processes to reduce environmental pollution and enhance resource utilization efficiency. This study aims to explore and optimize the application of green chemistry principles in pharmaceutical processes by designing novel catalysts, improving reaction pathways, and utilizing renewable raw materials, thereby achieving efficient and low-pollution drug production. A multidisciplinary approach was adopted, integrating computational chemistry simulations with experimental validation, to systematically evaluate the environmental impacts and economic feasibility under various process conditions. The results indicate that the introduction of bio-based solvents and selective catalysts significantly reduced waste emissions in traditional processes while improving the yield and purity of target products. Furthermore, this study proposes an evaluation system based on life cycle analysis to quantify the overall benefits of green processes. An innovative aspect of this research is the first application of machine learning algorithms for optimizing green process parameters, which substantially shortened the R cycle and enhanced process stability. The primary contributions lie in providing a feasible green transformation solution for the pharmaceutical industry and offering reference significance for sustainable development in other chemical engineering fields. The research findings are expected to promote the advancement of pharmaceutical engineering toward more environmentally friendly and economically viable directions.
Keywords：Green Chemistry; Pharmaceutical Engineering; Bio-Based Solvent; Machine Learning Optimization; Life Cycle Analysis
目 录
摘要 I
Abstract II
一、绪论 1
(一) 制药工程中绿色生产工艺的背景与意义 1
(二) 绿色生产工艺开发的研究现状分析 1
(三) 本文研究方法与技术路线 2
二、绿色制药工艺的关键技术分析 2
(一) 催化剂在绿色工艺中的应用研究 2
(二) 反应溶剂的选择与优化策略 3
(三) 废物最小化技术的实施路径 3
三、绿色制药工艺的环境影响评估 4
(一) 生命周期评价方法的应用 4
(二) 环境友好型工艺的设计原则 4
(三) 工艺改进对环境负荷的影响分析 5
四、绿色制药工艺的经济性与可行性研究 5
(一) 成本效益分析与案例研究 5
(二) 技术转化中的挑战与对策 6
(三) 绿色工艺推广的政策支持机制 7
结 论 8
参考文献 9
