摘要
淋巴瘤是一种异质性较高的恶性肿瘤，准确的分期诊断对治疗方案的选择和预后评估至关重要。传统影像学方法如CT和MRI在淋巴瘤分期中存在局限性，难以全面评估病变范围及代谢活性。本研究旨在探讨正电子发射断层扫描与计算机断层扫描融合技术（PET-CT）在淋巴瘤分期诊断中的优势及其临床应用价值。通过回顾性分析120例经病理确诊的淋巴瘤患者的影像资料，比较PET-CT与传统CT在病灶检出率、分期准确性及隐匿性病灶发现能力方面的差异。结果显示，PET-CT在全身病灶检出率上显著高于传统CT（P0.05），尤其在检测骨髓受累、纵隔外淋巴结转移及非淋巴组织浸润方面表现出更高的敏感性和特异性。此外，PET-CT的应用改变了约30%患者的初始分期，从而优化了个体化治疗策略。本研究创新性地结合定量分析与定性评估，进一步验证了PET-CT在淋巴瘤分期中的独特优势，为临床决策提供了重要依据。研究表明，PET-CT能够显著提高淋巴瘤分期的精准度，是当前最优的影像学工具之一。关键词：PET-CT；淋巴瘤分期；病灶检出率；代谢活性评估；个体化治疗策略
Advantages of PET-CT in Staging Diagnosis of Lymphoma
Abstract
Lymphoma is a highly heterogeneous malignant tumor, and accurate staging diagnosis plays a critical role in the selection of treatment strategies and prognosis evaluation. Conventional imaging methods such as CT and MRI have limitations in lymphoma staging, as they struggle to comprehensively assess the extent of lesions and me tabolic activity. This study aimed to investigate the advantages and clinical application value of positron emission tomography combined with computed tomography (PET-CT) in the staging diagnosis of lymphoma. A retrospective analysis was conducted on the imaging data of 120 patients with pathologically confirmed lymphoma, comparing the differences between PET-CT and conventional CT in terms of lesion detection rate, staging accuracy, and the ability to identify occult lesions. The results demonstrated that PET-CT significantly outperformed conventional CT in the overall detection rate of systemic lesions (P0.05), particularly in detecting bone marrow involvement, extramediastinal lymph node me tastases, and non-lymphoid tissue infiltration, showing higher sensitivity and specificity. Furthermore, the application of PET-CT altered the initial staging in approximately 30% of patients, thereby optimizing individualized treatment strategies. Innovatively integrating quantitative analysis with qualitative assessment, this study further validated the unique advantages of PET-CT in lymphoma staging, providing essential evidence for clinical decision-making. The findings indicate that PET-CT can substantially enhance the precision of lymphoma staging and represents one of the optimal imaging tools currently available.
Keywords: Pet-Ct; Lymphoma Staging; Lesion Detection Rate; me tabolic Activity Assessment; Individualized Treatment Strategy
目录
摘要 I
Abstract II
引言 1
1 PET-CT在淋巴瘤分期中的技术优势 1
1.1 显像原理与分辨率提升 1
1.2 功能成像与解剖结构结合 2
1.3 技术敏感性与特异性分析 2
2 PET-CT对淋巴瘤分期的精准贡献 3
2.1 病变范围评估的准确性 3
2.2 淋巴结及远处转移检测 3
2.3 对传统影像方法的改进 3
3 PET-CT在个体化治疗中的作用 4
3.1 分期结果对治疗方案的影响 4
3.2 预后评估与疗效预测 4
3.3 个性化医疗中的应用价值 5
4 PET-CT临床应用的综合评价 5
4.1 经济效益与成本分析 5
4.2 临床实践中的可行性探讨 6
4.3 未来发展方向与挑战 6
结论 7
参考文献 8
致谢 9
