摘 要
微反应器技术作为一种新兴的化学合成平台，在药物合成领域展现出巨大潜力。传统批量反应存在传质传热效率低、反应控制难等问题，而微反应器凭借其微米级通道结构，可实现高效的传质传热性能，为药物合成提供了更为精准可控的反应环境。本研究旨在系统探讨微反应器在药物合成中的优势与挑战，通过对比分析微反应器与传统反应器在多种典型药物合成反应中的表现，揭示其在提高反应选择性、缩短反应时间、降低副产物生成等方面的优势。研究采用实验验证与理论模拟相结合的方法，选取了具有代表性的药物合成反应体系进行研究，结果表明微反应器能够显著提升反应效率和产品质量。然而，该技术也面临一些挑战，如设备成本较高、放大生产难度较大等。本研究创新性地提出了基于微流控芯片的集成化解决方案，实现了多步连续反应的一体化操作，为解决上述问题提供了新思路。研究结果不仅为微反应器在药物合成领域的应用提供了理论依据和技术支持，也为推动微化工技术的发展做出了重要贡献。
关键词：微反应器 药物合成 传质传热
Abstract
Microreactor technology, as an emerging chemical synthesis platform, demonstrates significant potential in pharmaceutical synthesis. Traditional batch reactions suffer from low mass and heat transfer efficiency and difficulties in reaction control, whereas microreactors, with their microscale channel structures, achieve superior mass and heat transfer performance, providing a more precise and controllable reaction environment for drug synthesis. This study systematically investigates the advantages and challenges of microreactors in pharmaceutical synthesis by comparing their performance with traditional reactors in various typical drug synthesis reactions. The analysis reveals that microreactors excel in enhancing reaction selectivity, shortening reaction time, and reducing by-product formation. Employing a combination of experimental validation and theoretical simulation, this research selects representative drug synthesis reaction systems for investigation. The results indicate that microreactors can significantly improve reaction efficiency and product quality. However, challenges such as high equipment costs and difficulties in scale-up production remain. Innovatively, this study proposes an integrated solution based on microfluidic chips, achieving one-stop operation for multi-step continuous reactions, offering new approaches to addressing these issues. The findings not only provide theoretical basis and technical support for the application of microreactors in pharmaceutical synthesis but also contribute significantly to the advancement of microchemical technology.
Keyword:Microreactor Drug Synthesis Mass And Heat Transfer
目 录
引言 1
1微反应器的特性与药物合成需求 1
1.1微反应器的基本原理 1
1.2药物合成对反应器的要求 2
1.3微反应器与传统反应器对比 2
2微反应器在药物合成中的优势 3
2.1提高反应效率和选择性 3
2.2实现精准控制与安全性 3
2.3促进绿色化学发展 4
3微反应器应用于药物合成的技术挑战 4
3.1反应体系复杂化问题 4
3.2设备成本与放大生产 5
3.3在线监测与过程控制 5
4微反应器在药物合成中的应用前景 6
4.1新型药物研发中的作用 6
4.2工业化应用的可行性分析 6
4.3未来发展方向与策略建议 7
结论 7
参考文献 9
致谢 10
