摘 要
微反应器技术作为一种新兴的化工过程强化手段，在精细化学品合成领域展现出独特优势。传统反应器在放大过程中面临传质与传热效率低、反应选择性差等问题，而微反应器凭借其微尺度结构带来的高效传质传热特性，为解决上述问题提供了新思路。本研究旨在探讨微反应器在精细化学品合成中的放大效应，通过构建不同规模的微反应器系统，对典型精细化学品合成反应进行实验研究。采用计算流体力学模拟结合实验验证的方法，分析了微通道内流体流动、混合及反应特性随反应器尺寸变化的规律。结果表明，微反应器在放大过程中能够保持优异的传质传热性能，显著提高了目标产物的选择性和收率。特别地，本研究首次提出了基于特征长度比的放大准则，实现了从实验室规模到工业规模的平滑过渡。该准则不仅有效避免了传统放大方法中常见的性能衰减问题，还为微反应器在精细化学品合成领域的工业化应用提供了理论依据和技术支持，具有重要的学术价值和实际意义。
关键词：微反应器 精细化学品合成 传质传热性能
Abstract
Microreactor technology, as an emerging approach for process intensification in chemical engineering, demonstrates unique advantages in the synthesis of fine chemicals. Traditional reactors often encounter issues such as low mass and heat transfer efficiency and poor reaction selectivity during scale-up. In contrast, microreactors, leveraging their microscale structure, offer efficient mass and heat transfer characteristics, providing a novel solution to these challenges. This study investigates the scale-up effects of microreactors in fine chemical synthesis by constructing microreactor systems of various scales and conducting experimental studies on typical fine chemical synthesis reactions. By integrating computational fluid dynamics simulations with experimental validation, the study analyzes the patterns of fluid flow, mixing, and reaction characteristics within microchannels as reactor size changes. The results indicate that microreactors can maintain excellent mass and heat transfer performance during scale-up, significantly enhancing the selectivity and yield of target products. Notably, this research proposes a novel scale-up criterion based on characteristic length ratios for the first time, achieving a smooth transition from laboratory scale to industrial scale. This criterion not only effectively avoids the performance degradation commonly associated with traditional scale-up methods but also provides theoretical support and technical guidance for the industrial application of microreactors in fine chemical synthesis, offering significant academic value and practical implications.
Keyword:Microreactor Fine Chemicals Synthesis Mass And Heat Transfer Performance
目 录
引言 1
1微反应器放大效应的基础理论 1
1.1微反应器的工作原理 1
1.2放大效应的基本概念 2
1.3精细化学品合成的特点 2
2微反应器在精细化学品合成中的优势 3
2.1反应效率的提升 3
2.2产品质量的控制 4
2.3生产安全性的提高 4
3放大效应影响因素的研究 5
3.1反应条件的影响 5
3.2结构设计的作用 5
3.3材料选择的重要性 6
4放大效应的实际应用与挑战 6
4.1工业化应用案例 6
4.2技术瓶颈分析 7
4.3未来发展方向 7
结论 8
参考文献 9
致谢 10
