摘 要
随着人口老龄化加剧和心血管疾病发病率的持续上升，植入式心脏起搏器作为治疗心律失常的核心医疗器械，其性能优化与个性化设计成为当前研究的重要方向。本研究旨在通过多学科交叉方法，探索个性化植入式心脏起搏器的设计与优化策略，以提升设备的适配性、能效比及长期可靠性。研究基于患者个体解剖特征与生理需求，结合有限元分析、机器学习算法以及微电子技术，构建了一套完整的个性化起搏器设计框架。具体而言，通过采集患者的高精度心脏三维影像数据，建立了个性化的电生理模型，并利用仿真技术评估不同设计方案对心肌刺激效果的影响。同时，引入自适应控制算法优化起搏参数，实现了动态调节功能，显著提升了设备在复杂生理环境中的适应能力。
关键词：个性化植入式心脏起搏器 多学科交叉设计 电生理模型
Abstract
With the aging of the population and the increasing incidence of cardiovascular disease, as the core medical device and arrhythmia treatment device, its performance optimization and personalized design have become an important direction of current research. This study aims to explore the design and optimization strategies of personalized implantable pacemakers through a multidisciplinary approach to improve device adaptability, energy efficiency ratio and long-term reliability. Based on the individual anatomical characteristics and physiological needs of patients, combined with finite element analysis, machine learning algorithms and microelectronics technology, the research has constructed a complete set of personalized pacemaker design fr amework. Specifically, by collecting high-precision cardiac 3 D image data of patients, a personalized electrophysiological model was established, and the effects of different design schemes on the effect of myocardial stimulation was evaluated by using simulation techniques. At the same time, the adaptive control algorithm was introduced to optimize the pacing parameters, realizing the dynamic regulation function, which significantly improves the adaptability of the device in the complex physiological environment.
Keyword:Personalized Implantable Pacemaker Multi-Disciplinary Interdisciplinary Design Electrophysiological Model
目 录
1绪论 1
1.1心脏起搏器研究背景与意义 1
1.2个性化心脏起搏器的研究现状 1
1.3本文研究方法与技术路线 2
2个性化需求分析与设计框架 2
2.1患者生理特征的个性化需求 2
2.2数据驱动的个性化设计方法 3
2.3设计框架的构建与优化策略 3
2.4关键技术挑战与解决方案 4
3核心部件设计与性能优化 4
3.1起搏器电极的设计与选型 4
3.2能量管理系统的设计优化 5
3.3材料选择与生物相容性分析 5
3.4微型化与耐用性平衡策略 6
4系统集成与临床应用验证 6
4.1系统集成的技术实现路径 6
4.2实时监测与反馈控制机制 7
4.3临床试验的设计与实施方法 7
4.4数据分析与效果评估标准 8
结论 8
参考文献 10
致谢 11
