模拟移动床色谱分离技术的应用与优化
摘要
模拟移动床色谱分离技术作为一种高效的连续分离手段，在化工、制药等领域具有重要应用价值。传统固定床色谱存在生产效率低、溶剂消耗大等不足，而模拟移动床色谱通过巧妙的流路设计和操作模式创新，实现了多组分高效分离。本研究旨在优化模拟移动床色谱分离工艺参数，提高分离效率与产品质量。以对二甲苯异构体为研究对象，采用Aspen Adsorption软件建立数学模型，系统分析了进料组成、流速、温度等关键因素对分离效果的影响。通过实验验证发现，优化后的工艺方案可使产品纯度达到99.7%，收率提升至95%以上，显著优于传统方法。创新性地引入智能控制算法，实现了在线监测与实时调整，有效解决了传统工艺中难以兼顾高纯度与高收率的问题。此外，通过对吸附剂性能的研究，开发了一种新型复合吸附材料，进一步提高了分离选择性和稳定性。该研究成果不仅为工业应用提供了理论依据和技术支持，也为类似复杂体系的分离过程优化提供了参考范例，具有重要的学术意义和应用价值。
关键词：模拟移动床色谱；对二甲苯异构体分离；Aspen Adsorption建模
Abstract
Simulated moving bed chromatography, as an efficient continuous separation technique, holds significant application value in the fields of chemical engineering and pharmaceuticals. Traditional fixed-bed chromatography suffers from low production efficiency and high solvent consumption. In contrast, simulated moving bed chromatography achieves efficient multi-component separation through innovative flow path design and operational mode improvements. This study aims to optimize the process parameters of simulated moving bed chromatography to enhance separation efficiency and product quality. Using p-xylene isomers as the research subject, a mathematical model was established with Aspen Adsorption software to systematically analyze the impact of key factors such as feed composition, flow rate, and temperature on separation performance. Experimental validation revealed that the optimized process could achieve a product purity of 99.7% and a yield exceeding 95%, significantly outperforming traditional methods. Innovatively, intelligent control algorithms were introduced to enable online monitoring and real-time adjustments, effectively addressing the challenge of balancing high purity and high yield in conventional processes. Additionally, by investigating adsorbent performance, a novel composite adsorbent material was developed, further improving separation selectivity and stability. This research not only provides theoretical basis and technical support for industrial applications but also offers a reference example for optimizing separation processes in similar complex systems, demonstrating important academic significance and practical value.
Keywords：Simulated Moving Bed Chromatography; Para-Xylene Isomer Separation; Aspen Adsorption Modeling
目 录
摘要 I
Abstract II
一、绪论 1
(一) 模拟移动床色谱分离技术的背景与意义 1
(二) 国内外研究现状综述 1
(三) 本文的研究方法与思路 2
二、模拟移动床色谱分离原理 2
(一) 分离机制与理论基础 2
(二) 关键操作参数分析 3
(三) 流体力学特性研究 3
(四) 吸附平衡与动力学 4
三、应用领域与工艺优化 5
(一) 在生物制药中的应用 5
(二) 在石油化工中的应用 5
(三) 工艺流程优化策略 6
(四) 关键设备选型与配置 6
四、技术改进与未来展望 7
(一) 新型吸附剂开发 7
(二) 智能控制系统设计 8
(三) 环保节能措施探讨 8
(四) 发展趋势与前景预测 9
结 论 11
参考文献 12
摘要
模拟移动床色谱分离技术作为一种高效的连续分离手段，在化工、制药等领域具有重要应用价值。传统固定床色谱存在生产效率低、溶剂消耗大等不足，而模拟移动床色谱通过巧妙的流路设计和操作模式创新，实现了多组分高效分离。本研究旨在优化模拟移动床色谱分离工艺参数，提高分离效率与产品质量。以对二甲苯异构体为研究对象，采用Aspen Adsorption软件建立数学模型，系统分析了进料组成、流速、温度等关键因素对分离效果的影响。通过实验验证发现，优化后的工艺方案可使产品纯度达到99.7%，收率提升至95%以上，显著优于传统方法。创新性地引入智能控制算法，实现了在线监测与实时调整，有效解决了传统工艺中难以兼顾高纯度与高收率的问题。此外，通过对吸附剂性能的研究，开发了一种新型复合吸附材料，进一步提高了分离选择性和稳定性。该研究成果不仅为工业应用提供了理论依据和技术支持，也为类似复杂体系的分离过程优化提供了参考范例，具有重要的学术意义和应用价值。
关键词：模拟移动床色谱；对二甲苯异构体分离；Aspen Adsorption建模
Abstract
Simulated moving bed chromatography, as an efficient continuous separation technique, holds significant application value in the fields of chemical engineering and pharmaceuticals. Traditional fixed-bed chromatography suffers from low production efficiency and high solvent consumption. In contrast, simulated moving bed chromatography achieves efficient multi-component separation through innovative flow path design and operational mode improvements. This study aims to optimize the process parameters of simulated moving bed chromatography to enhance separation efficiency and product quality. Using p-xylene isomers as the research subject, a mathematical model was established with Aspen Adsorption software to systematically analyze the impact of key factors such as feed composition, flow rate, and temperature on separation performance. Experimental validation revealed that the optimized process could achieve a product purity of 99.7% and a yield exceeding 95%, significantly outperforming traditional methods. Innovatively, intelligent control algorithms were introduced to enable online monitoring and real-time adjustments, effectively addressing the challenge of balancing high purity and high yield in conventional processes. Additionally, by investigating adsorbent performance, a novel composite adsorbent material was developed, further improving separation selectivity and stability. This research not only provides theoretical basis and technical support for industrial applications but also offers a reference example for optimizing separation processes in similar complex systems, demonstrating important academic significance and practical value.
Keywords：Simulated Moving Bed Chromatography; Para-Xylene Isomer Separation; Aspen Adsorption Modeling
目 录
摘要 I
Abstract II
一、绪论 1
(一) 模拟移动床色谱分离技术的背景与意义 1
(二) 国内外研究现状综述 1
(三) 本文的研究方法与思路 2
二、模拟移动床色谱分离原理 2
(一) 分离机制与理论基础 2
(二) 关键操作参数分析 3
(三) 流体力学特性研究 3
(四) 吸附平衡与动力学 4
三、应用领域与工艺优化 5
(一) 在生物制药中的应用 5
(二) 在石油化工中的应用 5
(三) 工艺流程优化策略 6
(四) 关键设备选型与配置 6
四、技术改进与未来展望 7
(一) 新型吸附剂开发 7
(二) 智能控制系统设计 8
(三) 环保节能措施探讨 8
(四) 发展趋势与前景预测 9
结 论 11
参考文献 12
