摘 要
微反应器技术作为一种新兴的连续流化学合成方法，近年来在药物中间体合成领域展现出显著的优势。传统间歇式反应器在处理高活性、高毒性或不稳定化合物时存在效率低下和安全隐患等问题，而微反应器通过其高效的传质传热性能和精确的过程控制能力，为解决这些问题提供了新的途径。本研究旨在探讨微反应器技术在药物中间体合成中的应用潜力，并通过实验验证其在提高反应效率、降低副产物生成和优化产品质量方面的实际效果。研究方法包括设计并构建不同类型的微反应器系统，选择典型的药物中间体合成反应进行实验，通过对比传统间歇式反应器的实验数据，评估微反应器的性能。结果表明，微反应器在多个关键药物中间体的合成中表现出更高的转化率和选择性，显著减少了副产物的生成，同时提高了产品的纯度和一致性。特别是在处理对温度和压力敏感的化合物时，微反应器展现了其独特的优势。此外，本研究还发现微反应器能够实现更小的试剂消耗和更低的废物排放，符合绿色化学的发展趋势。综上所述，微反应器技术在药物中间体合成中的应用不仅提升了生产效率和产品质量，还为实现可持续发展的制药工业提供了新的技术支持。
关键词：微反应器技术；药物中间体合成；连续流化学；传质传热性能
Abstract
Microreactor technology, as an emerging continuous-flow chemical synthesis method, has demonstrated significant advantages in the field of drug intermediate synthesis in recent years. Traditional batch reactors face issues such as low efficiency and safety risks when dealing with highly active, toxic, or unstable compounds. In contrast, microreactors offer new solutions to these problems through their efficient mass and heat transfer capabilities and precise process control. This study aims to explore the application potential of microreactor technology in drug intermediate synthesis and experimentally verify its practical effects in enhancing reaction efficiency, reducing by-product formation, and optimizing product quality. The research methods include designing and constructing different types of microreactor systems, selecting typical drug intermediate synthesis reactions for experimentation, and evaluating the performance of microreactors by comparing experimental data with those from traditional batch reactors. The results indicate that microreactors exhibit higher conversion rates and selectivity in the synthesis of multiple key drug intermediates, significantly reducing by-product generation while improving product purity and consistency. Particularly, microreactors showcase their unique advantages when handling temperature- and pressure-sensitive compounds. Additionally, this study finds that microreactors enable smaller reagent consumption and lower waste emissions, aligning with the trends of green chemistry. In summary, the application of microreactor technology in drug intermediate synthesis not only enhances production efficiency and product quality but also provides new technological support for achieving sustainable development in the pharmaceutical industry.
Key Words：Microreactor Technology; Drug Intermediate Synthesis; Continuous Flow Chemistry; Mass and Heat Transfer Performance
目 录
摘 要 I
Abstract II
第1章 引言 1
第2章 微反应器技术概述 2
2.1 微反应器的定义与分类 2
2.2 微反应器的工作原理 2
2.3 微反应器在化学合成中的优势 3
2.4 微反应器技术的历史发展 4
第3章 药物中间体合成的传统方法与挑战 5
3.1 传统合成方法概述 5
3.2 传统方法的局限性分析 5
3.3 药物中间体合成中的常见问题 6
3.4 微反应器技术对传统方法的改进 7
第4章 微反应器在药物中间体合成中的应用案例 8
4.1 具体药物中间体的合成路径优化 8
4.2 微反应器在高效合成中的应用实例 8
4.3 微反应器技术对合成效率的影响评估 9
第5章 微反应器技术的未来发展与挑战 10
5.1 技术进步对药物中间体合成的影响预测 10
5.2 当前技术面临的挑战与解决方案探讨 10
5.3 政策与市场环境对技术发展的影响分析 11
结 论 12
参考文献 13
致 谢 14
