摘 要
药物纳米载体系统因其在提高药物疗效、降低毒副作用及实现靶向递送方面的显著优势，已成为现代药学研究的热点领域。本研究旨在设计一种多功能纳米载体平台，并通过优化其物理化学性能以提升药物递送效率。为此，采用聚合物自组装技术构建了具有刺激响应特性的纳米载体，该载体能够根据生理环境的变化实现药物的可控释放。同时，引入表面修饰策略以增强载体的生物相容性和靶向识别能力。实验结果表明，优化后的纳米载体展现出优异的载药能力和释放特性，在体内外模型中均表现出显著的治疗效果和较低的毒性反应。此外，该系统首次实现了对药物释放动力学的精确调控，为个性化治疗提供了新的可能性。本研究不仅为纳米载体的设计提供了理论依据，还为其临床转化奠定了重要基础，展现了广阔的应用前景。关键词：纳米载体; 药物递送; 刺激响应; 靶向识别; 释放动力学
Abstract
Drug nanocarrier systems have become a focal area in modern pharmaceutical research due to their significant advantages in enhancing drug efficacy, reducing toxic side effects, and enabling targeted delivery. This study aims to design a multifunctional nanocarrier platform and optimize its physicochemical properties to improve drug delivery efficiency. To achieve this, polymer self-assembly technology was employed to construct stimuli-responsive nanocarriers capable of controlled drug release in response to changes in the physiological environment. Additionally, surface modification strategies were introduced to enhance the biocompatibility and targeting recognition ability of the carriers. Experimental results demonstrated that the optimized nanocarriers exhibited excellent drug-loading capacity and release characteristics, showing significant therapeutic effects and low toxicity in both in vitro and in vivo models. Moreover, this system achieved precise control over drug release kinetics for the first time, offering new possibilities for personalized treatment. This research not only provides a theoretical basis for nanocarrier design but also lays an important foundation for its clinical translation, highlighting broad application prospects.Key words:NanoCarrier; Drug Delivery; Stimulus Response; Targeted Recognition; Release Kinetics
目 录
摘 要 I
Abstract II
引 言 1
第1章、药物纳米载体的设计原理 3
1.1、纳米载体材料选择策略 3
1.2、核壳结构设计与优化 3
1.3、表面功能化技术研究 3
第2章、药物递送效率的提升方法 5
2.1、靶向配体的选择与修饰 5
2.2、细胞摄取机制分析 5
2.3、体内分布特性优化 5
第3章、纳米载体稳定性与安全性评估 7
3.1、物理化学稳定性研究 7
3.2、生物相容性测试方法 7
3.3、毒性评价与改进措施 8
第4章、性能优化的实验验证与应用 9
4.1、体外释放行为研究 9
4.2、动物模型中的疗效验证 9
4.3、工业化生产可行性分析 9
结 论 11
参考文献 12
