摘要
肺癌靶向治疗显著改善了患者的生存预后，但伴随的皮肤毒性已成为影响患者生活质量的重要因素。本研究旨在系统分析肺癌靶向治疗相关皮肤毒性的临床特征及其潜在影响因素，为优化管理策略提供依据。研究纳入2018年至2023年间接受表皮生长因子受体酪氨酸激酶抑制剂（EGFR-TKI）治疗的456例非小细胞肺癌患者，通过回顾性分析其临床资料、实验室指标及皮肤毒性表现，结合问卷调查评估患者的生活质量。结果显示，皮肤毒性发生率为78.9%，主要表现为皮疹、瘙痒和甲沟炎，且与药物剂量、治疗持续时间及患者基线特征显著相关。进一步分析发现，早期干预措施可有效缓解症状并改善患者生活质量。本研究创新性地建立了皮肤毒性分级与生活质量评分的相关模型，揭示了个体化管理的重要性，为临床制定精准干预方案提供了新思路。关键词：肺癌靶向治疗；皮肤毒性；生活质量；EGFR-TKI；个体化管理
Clinical Characteristics Analysis of Skin Toxicity Associated with Targeted Therapy for Lung Cancer
Abstract
Lung cancer targeted therapy has significantly improved patient survival outcomes; however, associated skin toxicities have become a critical factor affecting patients' quality of life. This study aimed to systematically analyze the clinical characteristics and potential influencing factors of skin toxicities related to lung cancer targeted therapy, providing evidence for optimizing management strategies. A total of 456 non-small cell lung cancer patients who received epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) from 2018 to 2023 were included, and their clinical data, laboratory indicators, and skin toxicity manifestations were retrospectively analyzed. Patient quality of life was also assessed through questionnaire surveys. The results showed that the incidence of skin toxicity was 78.9%, with the main manifestations being rash, pruritus, and paronychia, which were significantly associated with drug dosage, treatment duration, and patient baseline characteristics. Further analysis revealed that early intervention measures could effectively alleviate symptoms and improve patients' quality of life. Innovatively, this study established a correlation model between skin toxicity grading and quality of life scores, highlighting the importance of individualized management and offering new insights for the development of precise intervention protocols in clinical practice.
Keywords: Lung Cancer Targeted Therapy; Skin Toxicity; Quality Of Life; EGFR-TKI; Individualized Management
目录
摘要 I
Abstract II
引言 1
1 肺癌靶向治疗概述 1
1.1 靶向治疗机制分析 1
1.2 常用靶向药物介绍 2
1.3 皮肤毒性研究意义 2
2 皮肤毒性临床表现特征 3
2.1 皮疹发生机制探讨 3
2.2 瘙痒与干燥症状分析 3
2.3 其他皮肤毒性表现 4
3 皮肤毒性的影响因素分析 4
3.1 患者个体差异评估 4
3.2 药物剂量与疗程关系 4
3.3 并发症对毒性的影响 5
4 皮肤毒性管理与干预策略 5
4.1 早期识别与监测方法 5
4.2 预防性护理措施实施 6
4.3 治疗性干预手段选择 6
结论 7
参考文献 8
致谢 9
