摘 要
抑郁症是常见的精神疾病，严重影响患者的生活质量和社会功能。为探索更有效的治疗方案，本研究旨在观察药物治疗联合心理干预对抑郁症患者的疗效。选取某医院收治的120例抑郁症患者作为研究对象，按照随机数字表法分为观察组和对照组各60例，两组均接受常规抗抑郁药物治疗，观察组在此基础上增加心理干预，包括认知行为疗法、支持性心理治疗等，每周进行2次，每次40分钟，持续治疗8周。通过汉密尔顿抑郁量表（HAMD）、社会功能缺陷筛选量表（SDSS）于治疗前及治疗后第4周末、第8周末评估患者的抑郁程度和社会功能情况。结果显示，治疗后两组患者的HAMD评分、SDSS评分均较治疗前降低，且观察组降低幅度明显大于对照组，差异有统计学意义（P0.05）。这表明药物治疗联合心理干预能更有效地改善抑郁症患者的抑郁症状和社会功能，与单纯药物治疗相比具有显著优势。本研究创新性地将心理干预融入抑郁症的常规治疗中，为临床提供了一种更为全面有效的治疗模式，有助于提高抑郁症患者的康复率，减少复发风险，对优化抑郁症治疗策略具有重要贡献。
关键词：抑郁症；药物治疗联合心理干预；认知行为疗法；社会功能改善；汉密尔顿抑郁量表
Abstract
Depression is a common mental disorder that significantly impairs patients' quality of life and social functioning. To explore more effective treatment strategies, this study aimed to investigate the efficacy of combined pharmacotherapy and psychological interventions in patients with depression. A total of 120 patients diagnosed with depression from a hospital were selected as subjects and randomly divided into an observation group and a control group, each comprising 60 patients. Both groups received routine antidepressant medication, while the observation group additionally underwent psychological interventions, including cognitive-behavioral therapy and supportive psychotherapy, conducted twice weekly for 40 minutes per session over an 8-week period. The Hamilton Depression Rating Scale (HAMD) and Social Dysfunction Screening Scale (SDSS) were used to assess the severity of depressive symptoms and social functioning before treatment and at the end of weeks 4 and 8. The results showed that HAMD and SDSS scores decreased in both groups after treatment compared to baseline, with a significantly greater reduction observed in the observation group (P0.05). This indicates that the combination of pharmacotherapy and psychological interventions can more effectively alleviate depressive symptoms and improve social functioning compared to pharmacotherapy alone, demonstrating a notable advantage. This study innovatively integrates psychological interventions into the conventional treatment of depression, providing a more comprehensive and effective therapeutic model for clinical practice. It contributes to enhancing recovery rates and reducing relapse risks, thereby optimizing treatment strategies for depression.
Keywords：Depression；Pharmacotherapy Combined With Psychological Intervention；Cognitive Behavioral Therapy；Social Function Improvement；Hamilton Depression Rating Scale
目 录
摘 要 I
Abstract II
引 言 1
第一章 研究背景与意义 2
1.1 抑郁症的流行病学特征 2
1.2 药物治疗的研究现状 2
1.3 心理干预的发展历程 3
第二章 研究对象与方法 5
2.1 研究对象的选择标准 5
2.2 药物治疗方案设计 5
2.3 心理干预措施实施 6
第三章 疗效评估指标与结果 8
3.1 临床症状改善情况 8
3.2 社会功能恢复状况 8
3.3 生活质量提升效果 9
第四章 影响因素分析与讨论 10
4.1 患者依从性的影响 10
4.2 不同治疗方法对比 10
4.3 综合干预的优势探讨 11
结 论 13
参考文献 14
致 谢 15
