摘要
纳米技术在药物传递系统中的应用已成为现代医药领域的重要研究方向，传统药物传递方式存在药物靶向性差、生物利用度低等问题，而纳米技术凭借其独特的物理化学性质为解决这些问题提供了新思路。本研究旨在探讨纳米技术在药物传递系统的最新进展，通过文献调研与实验分析相结合的方法，对多种纳米载体材料及其制备工艺进行深入研究。研究表明，基于聚合物、脂质体、金属纳米颗粒等构建的纳米载体能够有效提高药物的稳定性和靶向性，实现对特定细胞或组织的选择性递送，同时降低毒副作用。例如，磁性纳米颗粒可在外加磁场作用下实现精准定位；温敏型纳米凝胶可根据局部温度变化控制药物释放。此外，多功能复合纳米载体集成了诊断与治疗功能于一体，实现了诊疗一体化。该研究不仅拓展了纳米技术在生物医药领域的应用范围，还为开发新型高效药物传递系统提供了理论依据和技术支持，具有重要的学术价值和广阔的应用前景。
关键词：纳米技术；药物传递系统；纳米载体
Abstract
The application of nanotechnology in drug delivery systems has become a significant research direction in modern pharmaceutical science. Conventional drug delivery methods suffer from issues such as poor targeting and low bioavailability, whereas nanotechnology, leveraging its unique physicochemical properties, offers novel solutions to these challenges. This study investigates the latest advancements in the application of nanotechnology in drug delivery systems by integrating literature review and experimental analysis to conduct an in-depth study on various nanocarrier materials and their preparation processes. Research findings indicate that nanocarriers constructed based on polymers, liposomes, me tallic nanoparticles, among others, can effectively enhance drug stability and targeting, achieving selective delivery to specific cells or tissues while reducing toxicity. For instance, magnetic nanoparticles can achieve precise localization under the influence of an external magnetic field; thermosensitive nanogels can control drug release according to local temperature changes. Moreover, multifunctional composite nanocarriers integrate diagnostic and therapeutic functions, realizing theranostics. This research not only broadens the application scope of nanotechnology in the biomedical field but also provides theoretical foundations and technical support for developing new efficient drug delivery systems, holding important academic value and broad application prospects.
Keywords：Nanotechnology; Drug Delivery System; Nanocarrier
目 录
一、绪论 1
(一) 研究背景与意义 1
(二) 研究现状综述 1
(三) 研究方法概述 2
二、纳米载体材料的创新进展 2
(一) 新型纳米材料特性 2
(二) 材料生物相容性提升 3
(三) 智能响应型载体开发 4
三、靶向递送技术的新突破 4
(一) 主动靶向机制优化 4
(二) 被动靶向策略改进 5
(三) 多重靶向联合应用 6
四、临床转化与应用前景 6
(一) 临床前研究进展 6
(二) 已上市纳米药物分析 7
(三) 未来发展方向展望 8
结 论 10
参考文献 11
纳米技术在药物传递系统中的应用已成为现代医药领域的重要研究方向，传统药物传递方式存在药物靶向性差、生物利用度低等问题，而纳米技术凭借其独特的物理化学性质为解决这些问题提供了新思路。本研究旨在探讨纳米技术在药物传递系统的最新进展，通过文献调研与实验分析相结合的方法，对多种纳米载体材料及其制备工艺进行深入研究。研究表明，基于聚合物、脂质体、金属纳米颗粒等构建的纳米载体能够有效提高药物的稳定性和靶向性，实现对特定细胞或组织的选择性递送，同时降低毒副作用。例如，磁性纳米颗粒可在外加磁场作用下实现精准定位；温敏型纳米凝胶可根据局部温度变化控制药物释放。此外，多功能复合纳米载体集成了诊断与治疗功能于一体，实现了诊疗一体化。该研究不仅拓展了纳米技术在生物医药领域的应用范围，还为开发新型高效药物传递系统提供了理论依据和技术支持，具有重要的学术价值和广阔的应用前景。
关键词：纳米技术；药物传递系统；纳米载体
Abstract
The application of nanotechnology in drug delivery systems has become a significant research direction in modern pharmaceutical science. Conventional drug delivery methods suffer from issues such as poor targeting and low bioavailability, whereas nanotechnology, leveraging its unique physicochemical properties, offers novel solutions to these challenges. This study investigates the latest advancements in the application of nanotechnology in drug delivery systems by integrating literature review and experimental analysis to conduct an in-depth study on various nanocarrier materials and their preparation processes. Research findings indicate that nanocarriers constructed based on polymers, liposomes, me tallic nanoparticles, among others, can effectively enhance drug stability and targeting, achieving selective delivery to specific cells or tissues while reducing toxicity. For instance, magnetic nanoparticles can achieve precise localization under the influence of an external magnetic field; thermosensitive nanogels can control drug release according to local temperature changes. Moreover, multifunctional composite nanocarriers integrate diagnostic and therapeutic functions, realizing theranostics. This research not only broadens the application scope of nanotechnology in the biomedical field but also provides theoretical foundations and technical support for developing new efficient drug delivery systems, holding important academic value and broad application prospects.
Keywords：Nanotechnology; Drug Delivery System; Nanocarrier
目 录
一、绪论 1
(一) 研究背景与意义 1
(二) 研究现状综述 1
(三) 研究方法概述 2
二、纳米载体材料的创新进展 2
(一) 新型纳米材料特性 2
(二) 材料生物相容性提升 3
(三) 智能响应型载体开发 4
三、靶向递送技术的新突破 4
(一) 主动靶向机制优化 4
(二) 被动靶向策略改进 5
(三) 多重靶向联合应用 6
四、临床转化与应用前景 6
(一) 临床前研究进展 6
(二) 已上市纳米药物分析 7
(三) 未来发展方向展望 8
结 论 10
参考文献 11
