摘 要
妊娠期高血压疾病（HDP）是妊娠期常见的严重并发症，对母婴健康构成重大威胁。本研究旨在探讨早期筛查与干预对策的有效性，以降低HDP的发病率和改善妊娠结局。研究背景基于中国近年来HDP发病率的上升趋势及其对公共卫生系统的压力。研究目的在于通过系统性筛查和多层次干预措施，提高早期诊断率并优化治疗方案。研究方法包括回顾性分析2015年至2020年间在中国某大型医院就诊的1000例HDP患者的临床数据，以及前瞻性队列研究中随机选取的500名孕妇，采用多因素回归分析评估不同筛查工具和干预策略的效果。结果显示，使用生物标志物联合超声检查的早期筛查方法显著提高了HDP的早期诊断率（从30%提升至75%），且在干预组中，子痫前期和早产的发生率分别降低了40%和35%。主要贡献在于提出了基于生物标志物和超声技术的综合筛查模型，并验证了其临床应用价值。此外，本研究还开发了一套针对高风险孕妇的个性化干预方案，包括营养指导、心理支持和药物治疗的综合应用，显著改善了妊娠结局。
关键词：妊娠期高血压;早期筛查;多层次干预
Abstract
Hypertensive disease in pregnancy (HDP) is a common serious complication in pregnancy and poses a significant threat to maternal and infant health. This study aims to explore the effectiveness of early screening and intervention countermeasures to reduce the incidence of HDP and improve pregnancy outcomes. The research background is based on the increasing trend of HDP incidence in China in recent years and its pressure on the public health system. The study aims to improve early diagnosis rates and optimize treatment options through systematic screening and multilevel interventions. The methodology included a retrospective analysis of clinical data from 1000 HDP patients attending a large hospital in China between 2015 and 2020 and 20500 randomly selected pregnant women in a prospective cohort study using multivariate regression analysis to evaluate the efficacy of different screening tools and intervention strategies. The results showed that the early screening approach using biomarkers combined with ultrasound examination significantly improved the early diagnosis rate of HDP (from 30% to 75%), and reduced the incidence of preeclampsia and prematurity by 40% and 35%, respectively, in the intervention group. The main contribution lies in proposing a comprehensive screening model based on biomarker and ultrasound technology and the validation of its clinical application. Furthermore, this study developed a personalized intervention program for high-risk pregnant women, including a combined application of nutritional guidance, psychological support and medication, which significantly improved pregnancy outcomes.
Keywords：Hypertension in pregnancy; early screening; multilevel intervention
目 录
引 言 1
第一章 妊娠期高血压疾病的流行病学特征 2
1.1 妊娠期高血压疾病的发病率分析 2
1.2 高危人群的识别与分类 2
1.3 地理与社会经济因素的影响 3
第二章 早期筛查技术的评估与选择 4
2.1 现有筛查方法的比较研究 4
2.2 新型生物标志物的发现与应用 4
2.3 筛查技术的成本效益分析 5
第三章 干预措施的有效性与安全性评估 6
3.1 药物治疗的效果与副作用分析 6
3.2 生活方式干预的实施与效果评估 6
3.3 多学科协作模式下的干预策略 7
3.4 中国特定人群的干预案例研究 7
第四章 政策建议与未来研究方向 9
4.1 基于研究结果的政策制定建议 9
4.2 提高公众意识的策略探讨 9
4.3 未来研究的重点领域与方向 10
4.4 国际合作与知识共享的重要性分析 10
结 论 12
参考文献 13
致 谢 14
妊娠期高血压疾病（HDP）是妊娠期常见的严重并发症，对母婴健康构成重大威胁。本研究旨在探讨早期筛查与干预对策的有效性，以降低HDP的发病率和改善妊娠结局。研究背景基于中国近年来HDP发病率的上升趋势及其对公共卫生系统的压力。研究目的在于通过系统性筛查和多层次干预措施，提高早期诊断率并优化治疗方案。研究方法包括回顾性分析2015年至2020年间在中国某大型医院就诊的1000例HDP患者的临床数据，以及前瞻性队列研究中随机选取的500名孕妇，采用多因素回归分析评估不同筛查工具和干预策略的效果。结果显示，使用生物标志物联合超声检查的早期筛查方法显著提高了HDP的早期诊断率（从30%提升至75%），且在干预组中，子痫前期和早产的发生率分别降低了40%和35%。主要贡献在于提出了基于生物标志物和超声技术的综合筛查模型，并验证了其临床应用价值。此外，本研究还开发了一套针对高风险孕妇的个性化干预方案，包括营养指导、心理支持和药物治疗的综合应用，显著改善了妊娠结局。
关键词：妊娠期高血压;早期筛查;多层次干预
Abstract
Hypertensive disease in pregnancy (HDP) is a common serious complication in pregnancy and poses a significant threat to maternal and infant health. This study aims to explore the effectiveness of early screening and intervention countermeasures to reduce the incidence of HDP and improve pregnancy outcomes. The research background is based on the increasing trend of HDP incidence in China in recent years and its pressure on the public health system. The study aims to improve early diagnosis rates and optimize treatment options through systematic screening and multilevel interventions. The methodology included a retrospective analysis of clinical data from 1000 HDP patients attending a large hospital in China between 2015 and 2020 and 20500 randomly selected pregnant women in a prospective cohort study using multivariate regression analysis to evaluate the efficacy of different screening tools and intervention strategies. The results showed that the early screening approach using biomarkers combined with ultrasound examination significantly improved the early diagnosis rate of HDP (from 30% to 75%), and reduced the incidence of preeclampsia and prematurity by 40% and 35%, respectively, in the intervention group. The main contribution lies in proposing a comprehensive screening model based on biomarker and ultrasound technology and the validation of its clinical application. Furthermore, this study developed a personalized intervention program for high-risk pregnant women, including a combined application of nutritional guidance, psychological support and medication, which significantly improved pregnancy outcomes.
Keywords：Hypertension in pregnancy; early screening; multilevel intervention
目 录
引 言 1
第一章 妊娠期高血压疾病的流行病学特征 2
1.1 妊娠期高血压疾病的发病率分析 2
1.2 高危人群的识别与分类 2
1.3 地理与社会经济因素的影响 3
第二章 早期筛查技术的评估与选择 4
2.1 现有筛查方法的比较研究 4
2.2 新型生物标志物的发现与应用 4
2.3 筛查技术的成本效益分析 5
第三章 干预措施的有效性与安全性评估 6
3.1 药物治疗的效果与副作用分析 6
3.2 生活方式干预的实施与效果评估 6
3.3 多学科协作模式下的干预策略 7
3.4 中国特定人群的干预案例研究 7
第四章 政策建议与未来研究方向 9
4.1 基于研究结果的政策制定建议 9
4.2 提高公众意识的策略探讨 9
4.3 未来研究的重点领域与方向 10
4.4 国际合作与知识共享的重要性分析 10
结 论 12
参考文献 13
致 谢 14
