摘 要
本研究旨在深入探索口腔微生物群落与口腔健康之间的内在联系。通过对口腔微生物群落的细致分析，我们进一步理解了这些微生物如何影响口腔环境的稳态以及口腔健康。研究采用16S rRNA基因测序技术，对多组志愿者的口腔微生物进行了全面而深入的剖析，以期揭示微生物多样性与口腔疾病之间的潜在关联。实验设计涵盖了不同年龄、性别和生活习惯的受试者，以确保数据的广泛性和代表性。经过严格的样本处理和数据分析，我们发现口腔微生物群落的多样性与口腔健康状况密切相关。具体而言，健康的口腔环境往往伴随着更为丰富的微生物种类和均衡的菌群分布。相反，在口腔疾病患者中，微生物群落的多样性显著降低，且特定病原菌的丰度明显增加。此外，本研究还创新性地探讨了饮食习惯、口腔卫生习惯等因素对口腔微生物群落的影响，发现这些因素均能在一定程度上塑造口腔微生物的组成。
关键词：口腔微生物;口腔健康;饮食习惯
Abstract
This study aims to deeply explore the intrinsic link between the oral microbial community and oral health. Through a detailed analysis of the oral microbial community, we further understand how these microorganisms affect the homeostasis of the oral environment as well as oral health. The 16S rRNA gene sequencing technology was used to conduct a comprehensive and in-depth analysis of the oral microorganisms in multiple groups of volunteers, in order to reveal the potential association between microbial diversity and oral diseases. The experimental design covered subjects of different age, gender and lifestyle habits to ensure the universality and representativeness of the data. After rigorous sample processing and data analysis, we found that the diversity of the oral microbial community was closely associated with the oral health status. Specifically, a healthy oral environment is often accompanied by a more abundant microbial species and a balanced distribution of microflora. In contrast, in patients with oral diseases, the diversity of the microbial community was significantly reduced, with a marked increase in the abundance of specific pathogens. In addition, this study innovatively explored the influence of factors such as dietary habits and oral hygiene habits, and found that these factors could shape the composition of oral microorganisms to some extent.
Keywords：Oral microorganisms; oral health; dietary habits
目 录
引 言 1
第一章 口腔微生物群落的构成与特性 2
1.1 口腔微生物群落的多样性 2
1.2 口腔微生物群落的生态平衡 2
1.3 口腔微生物与宿主间的相互作用 3
第二章 口腔微生物群落与口腔健康的关系 4
2.1 口腔微生物群落与龋病的关系 4
2.2 口腔微生物群落与牙周病的关系 4
2.3 口腔微生物群落与其他口腔疾病的关系 5
2.4 口腔微生物群落的健康功能 5
第三章 影响口腔微生物群落的因素 7
3.1 饮食习惯对口腔微生物群落的影响 7
3.2 口腔卫生习惯对微生物群落的影响 7
3.3 年龄与性别对口腔微生物群落的影响 8
3.4 疾病状态对口腔微生物群落的影响 8
第四章 口腔微生物群落的调控与健康促进 10
4.1 口腔微生物群落的调控策略 10
4.2 益生菌在口腔健康中的应用 10
4.3 口腔微生物群落与全身健康的关系 11
4.4 未来口腔微生物群落研究的方向与挑战 11
结 论 13
参考文献 14
致 谢 15
本研究旨在深入探索口腔微生物群落与口腔健康之间的内在联系。通过对口腔微生物群落的细致分析，我们进一步理解了这些微生物如何影响口腔环境的稳态以及口腔健康。研究采用16S rRNA基因测序技术，对多组志愿者的口腔微生物进行了全面而深入的剖析，以期揭示微生物多样性与口腔疾病之间的潜在关联。实验设计涵盖了不同年龄、性别和生活习惯的受试者，以确保数据的广泛性和代表性。经过严格的样本处理和数据分析，我们发现口腔微生物群落的多样性与口腔健康状况密切相关。具体而言，健康的口腔环境往往伴随着更为丰富的微生物种类和均衡的菌群分布。相反，在口腔疾病患者中，微生物群落的多样性显著降低，且特定病原菌的丰度明显增加。此外，本研究还创新性地探讨了饮食习惯、口腔卫生习惯等因素对口腔微生物群落的影响，发现这些因素均能在一定程度上塑造口腔微生物的组成。
关键词：口腔微生物;口腔健康;饮食习惯
Abstract
This study aims to deeply explore the intrinsic link between the oral microbial community and oral health. Through a detailed analysis of the oral microbial community, we further understand how these microorganisms affect the homeostasis of the oral environment as well as oral health. The 16S rRNA gene sequencing technology was used to conduct a comprehensive and in-depth analysis of the oral microorganisms in multiple groups of volunteers, in order to reveal the potential association between microbial diversity and oral diseases. The experimental design covered subjects of different age, gender and lifestyle habits to ensure the universality and representativeness of the data. After rigorous sample processing and data analysis, we found that the diversity of the oral microbial community was closely associated with the oral health status. Specifically, a healthy oral environment is often accompanied by a more abundant microbial species and a balanced distribution of microflora. In contrast, in patients with oral diseases, the diversity of the microbial community was significantly reduced, with a marked increase in the abundance of specific pathogens. In addition, this study innovatively explored the influence of factors such as dietary habits and oral hygiene habits, and found that these factors could shape the composition of oral microorganisms to some extent.
Keywords：Oral microorganisms; oral health; dietary habits
目 录
引 言 1
第一章 口腔微生物群落的构成与特性 2
1.1 口腔微生物群落的多样性 2
1.2 口腔微生物群落的生态平衡 2
1.3 口腔微生物与宿主间的相互作用 3
第二章 口腔微生物群落与口腔健康的关系 4
2.1 口腔微生物群落与龋病的关系 4
2.2 口腔微生物群落与牙周病的关系 4
2.3 口腔微生物群落与其他口腔疾病的关系 5
2.4 口腔微生物群落的健康功能 5
第三章 影响口腔微生物群落的因素 7
3.1 饮食习惯对口腔微生物群落的影响 7
3.2 口腔卫生习惯对微生物群落的影响 7
3.3 年龄与性别对口腔微生物群落的影响 8
3.4 疾病状态对口腔微生物群落的影响 8
第四章 口腔微生物群落的调控与健康促进 10
4.1 口腔微生物群落的调控策略 10
4.2 益生菌在口腔健康中的应用 10
4.3 口腔微生物群落与全身健康的关系 11
4.4 未来口腔微生物群落研究的方向与挑战 11
结 论 13
参考文献 14
致 谢 15
