摘 要
人工肝支持系统作为重症肝炎治疗的重要辅助手段，近年来在临床应用中展现出显著的治疗潜力。本研究旨在探讨ALSS在重症肝炎患者中的临床应用效果及其对预后的影响。研究选取2020年1月至2023年6月期间收治的120例重症肝炎患者，随机分为对照组和实验组，每组60例。对照组采用常规内科治疗，实验组在此基础上联合应用ALSS治疗。通过对比两组患者的肝功能指标、凝血功能、炎症因子水平及生存率等参数，评估ALSS的临床疗效。研究结果显示，实验组患者治疗后总胆红素、丙氨酸氨基转移酶及天冬氨酸氨基转移酶水平较对照组显著下降，凝血酶原时间明显缩短，白细胞介素-6和肿瘤坏死因子-α等炎症因子水平显著降低。此外，实验组患者的28天生存率为86.7%，显著高于对照组的68.3%。
关键词：人工肝支持系统;重症肝炎;炎症因子
Abstract
As an important adjunct to the treatment of severe hepatitis, the artificial liver support system has shown significant therapeutic potential in clinical application in recent years. This study aimed to investigate the clinical effect of ALSS in patients with severe hepatitis and its impact on prognosis. A total of 120 patients with severe hepatitis admitted between January 2020 and June 2023 were randomly divided into control and experimental groups, 60 in each group. The control group was treated with conventional internal medicine, and the experimental group combined ALSS on this basis. The clinical efficacy of ALSS was evaluated by comparing parameters including liver function indexes, coagulation function, inflammatory factor level and survival rate in the two groups. The results showed that the levels of total bilirubin, alanine aminotransferase and aspartate aminotransferase decreased significantly compared with the control group, the prothrombin time was significantly shortened, and the levels of inflammatory factors such as interleukin-6 and tumor necrosis factor- α were significantly reduced. Moreover, the 28-day survival rate of patients in the experimental group was 86.7%, which was significantly higher than the 68.3% in the control group.
Keywords：Artificial liver support system; severe hepatitis; inflammatory factors
目 录
引 言 1
第一章 人工肝支持系统的技术原理与分类 2
1.1 人工肝支持系统的基本工作原理 2
1.2 非生物型人工肝支持系统 2
1.3 生物型人工肝支持系统 3
第二章 重症肝炎的病理生理特征与治疗需求 4
2.1 重症肝炎的病理生理机制 4
2.2 重症肝炎的临床表现与诊断标准 4
2.3 传统治疗方法的局限性分析 5
第三章 人工肝支持系统的临床应用效果评估 6
3.1 临床疗效评价指标体系的构建 6
3.2 肝功能改善效果的临床观察 6
3.3 并发症发生率及安全性分析 7
3.4 患者生存质量的影响评估 7
第四章 人工肝支持系统应用的优化策略与发展趋势 9
4.1 个体化治疗方案的设计与实施 9
4.2 多学科协作模式的建立与应用 9
4.3 新型材料与技术的研究进展 10
4.4 人工智能在人工肝领域的应用前景 11
结 论 12
参考文献 13
致 谢 14
人工肝支持系统作为重症肝炎治疗的重要辅助手段，近年来在临床应用中展现出显著的治疗潜力。本研究旨在探讨ALSS在重症肝炎患者中的临床应用效果及其对预后的影响。研究选取2020年1月至2023年6月期间收治的120例重症肝炎患者，随机分为对照组和实验组，每组60例。对照组采用常规内科治疗，实验组在此基础上联合应用ALSS治疗。通过对比两组患者的肝功能指标、凝血功能、炎症因子水平及生存率等参数，评估ALSS的临床疗效。研究结果显示，实验组患者治疗后总胆红素、丙氨酸氨基转移酶及天冬氨酸氨基转移酶水平较对照组显著下降，凝血酶原时间明显缩短，白细胞介素-6和肿瘤坏死因子-α等炎症因子水平显著降低。此外，实验组患者的28天生存率为86.7%，显著高于对照组的68.3%。
关键词：人工肝支持系统;重症肝炎;炎症因子
Abstract
As an important adjunct to the treatment of severe hepatitis, the artificial liver support system has shown significant therapeutic potential in clinical application in recent years. This study aimed to investigate the clinical effect of ALSS in patients with severe hepatitis and its impact on prognosis. A total of 120 patients with severe hepatitis admitted between January 2020 and June 2023 were randomly divided into control and experimental groups, 60 in each group. The control group was treated with conventional internal medicine, and the experimental group combined ALSS on this basis. The clinical efficacy of ALSS was evaluated by comparing parameters including liver function indexes, coagulation function, inflammatory factor level and survival rate in the two groups. The results showed that the levels of total bilirubin, alanine aminotransferase and aspartate aminotransferase decreased significantly compared with the control group, the prothrombin time was significantly shortened, and the levels of inflammatory factors such as interleukin-6 and tumor necrosis factor- α were significantly reduced. Moreover, the 28-day survival rate of patients in the experimental group was 86.7%, which was significantly higher than the 68.3% in the control group.
Keywords：Artificial liver support system; severe hepatitis; inflammatory factors
目 录
引 言 1
第一章 人工肝支持系统的技术原理与分类 2
1.1 人工肝支持系统的基本工作原理 2
1.2 非生物型人工肝支持系统 2
1.3 生物型人工肝支持系统 3
第二章 重症肝炎的病理生理特征与治疗需求 4
2.1 重症肝炎的病理生理机制 4
2.2 重症肝炎的临床表现与诊断标准 4
2.3 传统治疗方法的局限性分析 5
第三章 人工肝支持系统的临床应用效果评估 6
3.1 临床疗效评价指标体系的构建 6
3.2 肝功能改善效果的临床观察 6
3.3 并发症发生率及安全性分析 7
3.4 患者生存质量的影响评估 7
第四章 人工肝支持系统应用的优化策略与发展趋势 9
4.1 个体化治疗方案的设计与实施 9
4.2 多学科协作模式的建立与应用 9
4.3 新型材料与技术的研究进展 10
4.4 人工智能在人工肝领域的应用前景 11
结 论 12
参考文献 13
致 谢 14
